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Cohort profile : the Halland osteoarthritis (HALLOA) cohort-from knee pain to osteoarthritis: a longitudinal observational study in Sweden

Andersson, Maria L.E. LU orcid ; Haglund, Emma LU ; Aili, Katarina ; Bremander, Ann and Bergman, S. (2022) In BMJ Open 12(7).
Abstract

Purpose The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types. Participants The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in the southwest of Sweden. Enrolment took place from 2017 to 2019. The inclusion criteria were current knee pain, with no former known radiographic knee OA and no cruciate ligament rupture or rheumatological disorder. The participants were recruited: (1) when seeking care for knee pain in primary healthcare or (2) by advertisements in local... (More)

Purpose The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types. Participants The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in the southwest of Sweden. Enrolment took place from 2017 to 2019. The inclusion criteria were current knee pain, with no former known radiographic knee OA and no cruciate ligament rupture or rheumatological disorder. The participants were recruited: (1) when seeking care for knee pain in primary healthcare or (2) by advertisements in local newspapers. There are 306 individuals included in the study, mean age (SD) 51.7 (8.7) years and 69% are women. The baseline and follow-ups include clinical tests, radiographical examinations, blood samples, metabolic measures, pain pressure thresholds, tests of physical functions, daily physical activity types and patient-reported outcomes. Findings to date There were associations between metabolic factors and radiographic knee OA, even in those with normal body mass index at baseline. In addition, clinical hand OA was positively associated with fasting plasma glucose. We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain. Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment. Trial registration number ClinicalTrials.gov (NCT04928170).

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GENERAL MEDICINE (see Internal Medicine), Knee, Musculoskeletal disorders, Rheumatology
in
BMJ Open
volume
12
issue
7
article number
e057086
publisher
BMJ Publishing Group
external identifiers
  • pmid:35835523
  • scopus:85134137962
ISSN
2044-6055
DOI
10.1136/bmjopen-2021-057086
language
English
LU publication?
yes
id
1e686f6f-6e92-48f7-8354-d09eee21732c
date added to LUP
2022-09-08 12:08:17
date last changed
2024-11-12 02:29:58
@article{1e686f6f-6e92-48f7-8354-d09eee21732c,
  abstract     = {{<p>Purpose The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types. Participants The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in the southwest of Sweden. Enrolment took place from 2017 to 2019. The inclusion criteria were current knee pain, with no former known radiographic knee OA and no cruciate ligament rupture or rheumatological disorder. The participants were recruited: (1) when seeking care for knee pain in primary healthcare or (2) by advertisements in local newspapers. There are 306 individuals included in the study, mean age (SD) 51.7 (8.7) years and 69% are women. The baseline and follow-ups include clinical tests, radiographical examinations, blood samples, metabolic measures, pain pressure thresholds, tests of physical functions, daily physical activity types and patient-reported outcomes. Findings to date There were associations between metabolic factors and radiographic knee OA, even in those with normal body mass index at baseline. In addition, clinical hand OA was positively associated with fasting plasma glucose. We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain. Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment. Trial registration number ClinicalTrials.gov (NCT04928170). </p>}},
  author       = {{Andersson, Maria L.E. and Haglund, Emma and Aili, Katarina and Bremander, Ann and Bergman, S.}},
  issn         = {{2044-6055}},
  keywords     = {{GENERAL MEDICINE (see Internal Medicine); Knee; Musculoskeletal disorders; Rheumatology}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Cohort profile : the Halland osteoarthritis (HALLOA) cohort-from knee pain to osteoarthritis: a longitudinal observational study in Sweden}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2021-057086}},
  doi          = {{10.1136/bmjopen-2021-057086}},
  volume       = {{12}},
  year         = {{2022}},
}