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Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation

Zeller-Plumhoff, Berit LU ; Akkineni, Ashwini Rahul ; Helmholz, Heike ; Orlov, Dmytro LU orcid ; Mosshammer, Maria ; Kühl, Michael ; Willumeit-Römer, Regine and Gelinsky, Michael (2022) In npj Materials Degradation 6(1).
Abstract

Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O2) consumption is non-negligible. In this study, we give experimental proof of O2 consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg–6 wt%Ag and Mg–5 wt%Gd in Hanks’ balanced salt solution and Dulbecco’s modified Eagle’s medium. We show that O2 consumption and hydrogen evolution are inversely correlated and that O2 concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Materials Degradation
volume
6
issue
1
article number
95
publisher
Nature Publishing Group
external identifiers
  • scopus:85142162325
ISSN
2397-2106
DOI
10.1038/s41529-022-00302-9
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022, The Author(s).
id
1e7c9748-07b5-425a-bbdc-e1aac9e841ab
date added to LUP
2022-12-11 21:19:21
date last changed
2023-10-06 13:52:56
@article{1e7c9748-07b5-425a-bbdc-e1aac9e841ab,
  abstract     = {{<p>Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O<sub>2</sub>) consumption is non-negligible. In this study, we give experimental proof of O<sub>2</sub> consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg–6 wt%Ag and Mg–5 wt%Gd in Hanks’ balanced salt solution and Dulbecco’s modified Eagle’s medium. We show that O<sub>2</sub> consumption and hydrogen evolution are inversely correlated and that O<sub>2</sub> concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing.</p>}},
  author       = {{Zeller-Plumhoff, Berit and Akkineni, Ashwini Rahul and Helmholz, Heike and Orlov, Dmytro and Mosshammer, Maria and Kühl, Michael and Willumeit-Römer, Regine and Gelinsky, Michael}},
  issn         = {{2397-2106}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{npj Materials Degradation}},
  title        = {{Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation}},
  url          = {{http://dx.doi.org/10.1038/s41529-022-00302-9}},
  doi          = {{10.1038/s41529-022-00302-9}},
  volume       = {{6}},
  year         = {{2022}},
}