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Clinical and microbiological features of Actinotignum bacteremia : a retrospective observational study of 57 cases

Pedersen, H.; Senneby, E. LU and Rasmussen, M. LU (2017) In European Journal of Clinical Microbiology and Infectious Diseases 36(5). p.791-796
Abstract

The purpose of this study was to investigate the incidence, clinical presentation, and prognosis of Actinotignum bacteremia in southern Sweden. Actinotignum isolates in blood cultures were identified retrospectively between 1st January 2012 and 31st March 2016 through searches in the clinical microbiology laboratory database. The population covered by this laboratory is approximately 1.3 million. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for species determination. Etests were used for minimum inhibitory concentration (MIC) determination. The patients’ medical charts were reviewed. Fifty-eight episodes in fifty-seven patients with Actinotignum bacteremia were identified (A.... (More)

The purpose of this study was to investigate the incidence, clinical presentation, and prognosis of Actinotignum bacteremia in southern Sweden. Actinotignum isolates in blood cultures were identified retrospectively between 1st January 2012 and 31st March 2016 through searches in the clinical microbiology laboratory database. The population covered by this laboratory is approximately 1.3 million. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for species determination. Etests were used for minimum inhibitory concentration (MIC) determination. The patients’ medical charts were reviewed. Fifty-eight episodes in fifty-seven patients with Actinotignum bacteremia were identified (A. schaalii = 53, A. sanguinis = 1, A. urinale = 2, and Actinotignum species = 3), which corresponds to an incidence of 11 cases per million inhabitants. Fifty-one percent of the isolates were in pure culture. The MICs were low for β-lactam antibiotics, whereas high MICs were recorded for ciprofloxacin and trimethoprim. Patients had a median age of 82 years, 72% were male, and a majority had underlying urological conditions. Thirty-six of the patients were diagnosed with a focus from the urinary tract. Thirty-one patients developed severe sepsis and nine patients died during the hospital stay. Our study is the largest of Actinotignum bacteremia and demonstrates that it is a condition with a significant fatality that affects elderly persons with underlying conditions. β-Lactams represent a rational treatment option.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Microbiology and Infectious Diseases
volume
36
issue
5
pages
791 - 796
publisher
Springer
external identifiers
  • scopus:85003794156
  • wos:000399694500005
ISSN
0934-9723
DOI
10.1007/s10096-016-2862-y
language
English
LU publication?
yes
id
1e8f940c-58fd-47d1-bd80-f0f827f3ccdc
date added to LUP
2016-12-23 08:16:06
date last changed
2018-04-08 04:52:13
@article{1e8f940c-58fd-47d1-bd80-f0f827f3ccdc,
  abstract     = {<p>The purpose of this study was to investigate the incidence, clinical presentation, and prognosis of Actinotignum bacteremia in southern Sweden. Actinotignum isolates in blood cultures were identified retrospectively between 1st January 2012 and 31st March 2016 through searches in the clinical microbiology laboratory database. The population covered by this laboratory is approximately 1.3 million. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for species determination. Etests were used for minimum inhibitory concentration (MIC) determination. The patients’ medical charts were reviewed. Fifty-eight episodes in fifty-seven patients with Actinotignum bacteremia were identified (A. schaalii = 53, A. sanguinis = 1, A. urinale = 2, and Actinotignum species = 3), which corresponds to an incidence of 11 cases per million inhabitants. Fifty-one percent of the isolates were in pure culture. The MICs were low for β-lactam antibiotics, whereas high MICs were recorded for ciprofloxacin and trimethoprim. Patients had a median age of 82 years, 72% were male, and a majority had underlying urological conditions. Thirty-six of the patients were diagnosed with a focus from the urinary tract. Thirty-one patients developed severe sepsis and nine patients died during the hospital stay. Our study is the largest of Actinotignum bacteremia and demonstrates that it is a condition with a significant fatality that affects elderly persons with underlying conditions. β-Lactams represent a rational treatment option.</p>},
  author       = {Pedersen, H. and Senneby, E. and Rasmussen, M.},
  issn         = {0934-9723},
  language     = {eng},
  number       = {5},
  pages        = {791--796},
  publisher    = {Springer},
  series       = {European Journal of Clinical Microbiology and Infectious Diseases},
  title        = {Clinical and microbiological features of Actinotignum bacteremia : a retrospective observational study of 57 cases},
  url          = {http://dx.doi.org/10.1007/s10096-016-2862-y},
  volume       = {36},
  year         = {2017},
}