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Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOEɛ4 in the Betula Cohort

Oudin, Anna LU ; Andersson, John; Sundström, Anna; Nordin Adolfsson, Annelie; Oudin Åström, Daniel LU ; Adolfsson, Rolf; Forsberg, Bertil and Nordin, Maria (2019) In Journal of Alzheimer's disease : JAD 71(3). p.733-740
Abstract

It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOEɛ4 carriers than in non-carriers. Air pollution and interaction with APOEɛ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up.... (More)

It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOEɛ4 carriers than in non-carriers. Air pollution and interaction with APOEɛ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOEɛ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOEɛ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOEɛ4 carriers than in the total population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Alzheimer's disease : JAD
volume
71
issue
3
pages
733 - 740
publisher
IOS Press
external identifiers
  • scopus:85073082152
ISSN
1387-2877
DOI
10.3233/JAD-181037
language
English
LU publication?
yes
id
1ebbf5c4-e627-4e13-93ad-138ace8358f0
date added to LUP
2019-10-02 12:33:16
date last changed
2019-10-29 05:57:31
@article{1ebbf5c4-e627-4e13-93ad-138ace8358f0,
  abstract     = {<p>It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOEɛ4 carriers than in non-carriers. Air pollution and interaction with APOEɛ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOEɛ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOEɛ4 on the association (p-value for interaction &gt; 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOEɛ4 carriers than in the total population.</p>},
  author       = {Oudin, Anna and Andersson, John and Sundström, Anna and Nordin Adolfsson, Annelie and Oudin Åström, Daniel and Adolfsson, Rolf and Forsberg, Bertil and Nordin, Maria},
  issn         = {1387-2877},
  language     = {eng},
  month        = {10},
  number       = {3},
  pages        = {733--740},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's disease : JAD},
  title        = {Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOEɛ4 in the Betula Cohort},
  url          = {http://dx.doi.org/10.3233/JAD-181037},
  volume       = {71},
  year         = {2019},
}