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Positive patch test reactions to oxidized limonene: exposure and relevance

Christensson, Johanna Brared; Andersen, Klaus E.; Bruze, Magnus LU ; Johansen, Jeanne D.; Garcia-Bravo, Begona; Gimenez Arnau, Ana; Goh, Chee-Leok; Nixon, Rosemary and White, Ian R. (2014) In Contact Dermatitis 71(5). p.264-272
Abstract
Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain,... (More)
Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, autoxidation, fragrance allergy, hydroperoxide, limonene, oxidation products, patch test, relevance, terpenes
in
Contact Dermatitis
volume
71
issue
5
pages
264 - 272
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000344350000002
  • scopus:84930240957
ISSN
0105-1873
DOI
10.1111/cod.12285
language
English
LU publication?
yes
id
1ed94b9d-77ab-4092-8652-00cfb5fe2d96 (old id 4875058)
date added to LUP
2015-01-07 10:26:07
date last changed
2017-10-01 03:22:22
@article{1ed94b9d-77ab-4092-8652-00cfb5fe2d96,
  abstract     = {Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.},
  author       = {Christensson, Johanna Brared and Andersen, Klaus E. and Bruze, Magnus and Johansen, Jeanne D. and Garcia-Bravo, Begona and Gimenez Arnau, Ana and Goh, Chee-Leok and Nixon, Rosemary and White, Ian R.},
  issn         = {0105-1873},
  keyword      = {allergic contact dermatitis,autoxidation,fragrance allergy,hydroperoxide,limonene,oxidation products,patch test,relevance,terpenes},
  language     = {eng},
  number       = {5},
  pages        = {264--272},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Positive patch test reactions to oxidized limonene: exposure and relevance},
  url          = {http://dx.doi.org/10.1111/cod.12285},
  volume       = {71},
  year         = {2014},
}