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Specificity of cyclic AMP potentiation of glucose-stimulated insulin release

Lernmark, Åke LU orcid (1974) In Hormone Research in Paediatrics 5(4). p.227-233
Abstract

The insulin-releasing activities of cyclic and non-cyclic nucleotides were studied with isolated pancreatic islets from obese-hyperglycemic mice. Substitution of cylidine, inosine, guanosine, or uridine for the adenosine moeity of cyclic 3ʹ,5ʹ-adenosine monophosphate was associated with a total loss of insulin-releasing ability. The 5ʹ-nucleotide triphosphate derivatives of these nucleotides were all ineffective. It is suggested that cyclic AMP potentiation of glucose-stimulated insulin release in the mouse is highly specific for this nucleotide.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cyclic AMP, Cyclic mononucleotides, Insulin release, Isolated islets
in
Hormone Research in Paediatrics
volume
5
issue
4
pages
7 pages
publisher
Karger
external identifiers
  • scopus:0016258258
  • pmid:4366458
ISSN
1663-2818
DOI
10.1159/000178635
language
English
LU publication?
no
id
1f3091c3-4853-4d43-b719-d8520b64f9d6
date added to LUP
2019-12-12 23:36:04
date last changed
2025-10-14 12:19:03
@article{1f3091c3-4853-4d43-b719-d8520b64f9d6,
  abstract     = {{<p>The insulin-releasing activities of cyclic and non-cyclic nucleotides were studied with isolated pancreatic islets from obese-hyperglycemic mice. Substitution of cylidine, inosine, guanosine, or uridine for the adenosine moeity of cyclic 3ʹ,5ʹ-adenosine monophosphate was associated with a total loss of insulin-releasing ability. The 5ʹ-nucleotide triphosphate derivatives of these nucleotides were all ineffective. It is suggested that cyclic AMP potentiation of glucose-stimulated insulin release in the mouse is highly specific for this nucleotide.</p>}},
  author       = {{Lernmark, Åke}},
  issn         = {{1663-2818}},
  keywords     = {{Cyclic AMP; Cyclic mononucleotides; Insulin release; Isolated islets}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{227--233}},
  publisher    = {{Karger}},
  series       = {{Hormone Research in Paediatrics}},
  title        = {{Specificity of cyclic AMP potentiation of glucose-stimulated insulin release}},
  url          = {{http://dx.doi.org/10.1159/000178635}},
  doi          = {{10.1159/000178635}},
  volume       = {{5}},
  year         = {{1974}},
}