Orthostatic Hypotension Predicts Incidence of Heart Failure: The Malmö Preventive Project.
Fedorowski, Artur LU
; Engström, Gunnar
LU
; Hedblad, Bo
LU
and Melander, Olle
LU
(2010)
In American Journal of Hypertension
23.
p.1209-1215
- Abstract
- BackgroundThe presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown.MethodsIn this Swedish population-based prospective study (the Malmö Preventive Project), the incidence of HF in relation to baseline OH, defined as decrease in systolic (SBP) >/=20 mm Hg and/or diastolic blood pressure (DBP) >/=10 mm Hg upon standing, was studied in 32,669 middle-aged individuals (68.2% men; mean age, 45.6 +/- 7.4 years) over a mean follow-up period of 24 years.ResultsAt baseline, 1,991 (6.1%) participants were found to have OH. During follow-up, 1,293 persons (4.0%, mean age at presentation: 67.9 +/- 7.9... (More)
- BackgroundThe presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown.MethodsIn this Swedish population-based prospective study (the Malmö Preventive Project), the incidence of HF in relation to baseline OH, defined as decrease in systolic (SBP) >/=20 mm Hg and/or diastolic blood pressure (DBP) >/=10 mm Hg upon standing, was studied in 32,669 middle-aged individuals (68.2% men; mean age, 45.6 +/- 7.4 years) over a mean follow-up period of 24 years.ResultsAt baseline, 1,991 (6.1%) participants were found to have OH. During follow-up, 1,293 persons (4.0%, mean age at presentation: 67.9 +/- 7.9 years) were hospitalized for HF, 912 (2.8%) of whom without previous or concurrent myocardial infarction (MI) ("nonischemic HF"). Among those who had OH, the corresponding numbers were 6.5% (n = 129) and 4.6% (n = 92), respectively. In multivariable Cox proportional hazard models, taking conventional HF risk factors into account, OH was associated with both all-cause and "nonischemic" HF events (hazard ratio (HR): 1.22, 1.01-1.46, and 1.31, 1.05-1.63, respectively). The association between OH and HF was more pronounced in younger (aged <45 years) than older individuals (2.05; 1.31-3.22 vs. 1.12, 0.92-1.38, respectively, P < 0.001 for interaction between age and OH on incident HF).ConclusionsThe presence of OH among middle-aged adults predicts long-term incidence of HF hospitalizations independently of conventional risk factors. Our findings add to the available data indicating that OH is a potential independent cardiovascular risk factor, especially with regard to younger individuals and nonischemic HF.American Journal of Hypertension (2010). doi:10.1038/ajh.2010.150. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1644626
- author
- Fedorowski, Artur
LU
; Engström, Gunnar
LU
; Hedblad, Bo
LU
and Melander, Olle
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Hypertension
- volume
- 23
- pages
- 1209 - 1215
- publisher
- Oxford University Press
- external identifiers
-
- wos:000283531900011
- pmid:20651699
- scopus:77958091095
- pmid:20651699
- ISSN
- 1941-7225
- DOI
- 10.1038/ajh.2010.150
- language
- English
- LU publication?
- yes
- id
- 1f5cbedc-9d11-4ef3-beb3-bb59baba8ca3 (old id 1644626)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20651699?dopt=Abstract
- date added to LUP
- 2016-04-04 09:25:30
- date last changed
- 2024-01-12 13:11:47
@article{1f5cbedc-9d11-4ef3-beb3-bb59baba8ca3,
abstract = {{BackgroundThe presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown.MethodsIn this Swedish population-based prospective study (the Malmö Preventive Project), the incidence of HF in relation to baseline OH, defined as decrease in systolic (SBP) >/=20 mm Hg and/or diastolic blood pressure (DBP) >/=10 mm Hg upon standing, was studied in 32,669 middle-aged individuals (68.2% men; mean age, 45.6 +/- 7.4 years) over a mean follow-up period of 24 years.ResultsAt baseline, 1,991 (6.1%) participants were found to have OH. During follow-up, 1,293 persons (4.0%, mean age at presentation: 67.9 +/- 7.9 years) were hospitalized for HF, 912 (2.8%) of whom without previous or concurrent myocardial infarction (MI) ("nonischemic HF"). Among those who had OH, the corresponding numbers were 6.5% (n = 129) and 4.6% (n = 92), respectively. In multivariable Cox proportional hazard models, taking conventional HF risk factors into account, OH was associated with both all-cause and "nonischemic" HF events (hazard ratio (HR): 1.22, 1.01-1.46, and 1.31, 1.05-1.63, respectively). The association between OH and HF was more pronounced in younger (aged <45 years) than older individuals (2.05; 1.31-3.22 vs. 1.12, 0.92-1.38, respectively, P < 0.001 for interaction between age and OH on incident HF).ConclusionsThe presence of OH among middle-aged adults predicts long-term incidence of HF hospitalizations independently of conventional risk factors. Our findings add to the available data indicating that OH is a potential independent cardiovascular risk factor, especially with regard to younger individuals and nonischemic HF.American Journal of Hypertension (2010). doi:10.1038/ajh.2010.150.}},
author = {{Fedorowski, Artur and Engström, Gunnar and Hedblad, Bo and Melander, Olle}},
issn = {{1941-7225}},
language = {{eng}},
pages = {{1209--1215}},
publisher = {{Oxford University Press}},
series = {{American Journal of Hypertension}},
title = {{Orthostatic Hypotension Predicts Incidence of Heart Failure: The Malmö Preventive Project.}},
url = {{https://lup.lub.lu.se/search/files/5320656/1671803.pdf}},
doi = {{10.1038/ajh.2010.150}},
volume = {{23}},
year = {{2010}},
}