Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene
(2023) In Contact Dermatitis- Abstract
BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.
OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.
METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.
RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence... (More)
BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.
OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.
METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.
RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence interval) = 4.15 (3.01-5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.
CONCLUSIONS: Simultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co-sensitization of the cosmetic allergens.
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- author
- Sukakul, Thanisorn LU ; Bruze, Magnus LU ; Mowitz, Martin LU ; Bergendorff, Ola LU ; Björk, Jonas LU ; Dahlin, Jakob LU and Svedman, Cecilia LU
- organization
-
- Occupational and Environmental Dermatology (research group)
- Dermatology (research group)
- Dermatology and Venereology (Lund)
- EPI@LUND (research group)
- Surgery and public health (research group)
- eSSENCE: The e-Science Collaboration
- Division of Occupational and Environmental Medicine, Lund University
- EpiHealth: Epidemiology for Health
- Environmental Epidemiology (research group)
- publishing date
- 2023-10-18
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Contact Dermatitis
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85174228209
- pmid:37852634
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.14445
- language
- English
- LU publication?
- yes
- additional info
- © 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
- id
- 1f6e0289-6b88-4e98-a0fa-dd2df138041f
- date added to LUP
- 2023-11-20 09:23:32
- date last changed
- 2024-04-18 06:53:26
@article{1f6e0289-6b88-4e98-a0fa-dd2df138041f, abstract = {{<p>BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.</p><p>OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.</p><p>METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.</p><p>RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence interval) = 4.15 (3.01-5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.</p><p>CONCLUSIONS: Simultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co-sensitization of the cosmetic allergens.</p>}}, author = {{Sukakul, Thanisorn and Bruze, Magnus and Mowitz, Martin and Bergendorff, Ola and Björk, Jonas and Dahlin, Jakob and Svedman, Cecilia}}, issn = {{0105-1873}}, language = {{eng}}, month = {{10}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene}}, url = {{http://dx.doi.org/10.1111/cod.14445}}, doi = {{10.1111/cod.14445}}, year = {{2023}}, }