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Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene

Sukakul, Thanisorn LU orcid ; Bruze, Magnus LU ; Mowitz, Martin LU ; Bergendorff, Ola LU ; Björk, Jonas LU ; Dahlin, Jakob LU and Svedman, Cecilia LU (2023) In Contact Dermatitis
Abstract

BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.

OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.

METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.

RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence... (More)

BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.

OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.

METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.

RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence interval) = 4.15 (3.01-5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.

CONCLUSIONS: Simultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co-sensitization of the cosmetic allergens.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Contact Dermatitis
publisher
Wiley-Blackwell
external identifiers
  • scopus:85174228209
  • pmid:37852634
ISSN
0105-1873
DOI
10.1111/cod.14445
language
English
LU publication?
yes
additional info
© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
id
1f6e0289-6b88-4e98-a0fa-dd2df138041f
date added to LUP
2023-11-20 09:23:32
date last changed
2024-04-18 06:53:26
@article{1f6e0289-6b88-4e98-a0fa-dd2df138041f,
  abstract     = {{<p>BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.</p><p>OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.</p><p>METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.</p><p>RESULTS: Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value &lt;0.001, odds ratio (95% confidence interval) = 4.15 (3.01-5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.</p><p>CONCLUSIONS: Simultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co-sensitization of the cosmetic allergens.</p>}},
  author       = {{Sukakul, Thanisorn and Bruze, Magnus and Mowitz, Martin and Bergendorff, Ola and Björk, Jonas and Dahlin, Jakob and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  language     = {{eng}},
  month        = {{10}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene}},
  url          = {{http://dx.doi.org/10.1111/cod.14445}},
  doi          = {{10.1111/cod.14445}},
  year         = {{2023}},
}