Pre-eclampsia is a potent risk factor for deterioration of retinopathy during pregnancy in Type 1 diabetic patients
(1997) In Diabetic Medicine 14(12). p.1059-1065- Abstract
- The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p < 0.001). Pregnant patients with... (More)
- The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p < 0.001). Pregnant patients with sight-threatening deterioration of retinopathy had higher HbA1c levels than those without (p = 0.028 and the decrement in HbA1c between the 6-14th and the 20th week of gestation was more pronounced (p = 0.006). In those patients who developed pre-eclampsia during pregnancy, deterioration of retinopathy ocurred more frequently compared to those without pre-eclampsia (4/8 vs 5/65; p = 0.005). In conclusion, sight-threatening deterioration of retinopathy was not more common during pregnancy in IDDM patients than among age- and duration-matched control patients. In pregnant patients, deterioration of retinopathy was associated with the pregestational degree of metabolic control as well as with a rapidly improved glycaemic control acheived during pregnancy. Among those in whom deterioration occurred during pregnancy, pre-eclampsia was a potent risk factor. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111189
- author
- Lövestam Adrian, Monica LU ; Agardh, Carl-David LU ; Åberg, Anders E LU and Agardh, Elisabet LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pre-eclampsia, pregnancy, retinopathy, type 1 diabetes
- in
- Diabetic Medicine
- volume
- 14
- issue
- 12
- pages
- 1059 - 1065
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9455934
- scopus:0031455055
- ISSN
- 1464-5491
- DOI
- 10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Ophthalmology (Lund) (013043000), Unit on Vascular Diabetic Complications (013241510), Department of Obstetrics and Gynaecology (Lund) (013018000)
- id
- 1f9ee324-cb82-4a57-94d3-22d2d2da3c28 (old id 1111189)
- date added to LUP
- 2016-04-01 15:44:36
- date last changed
- 2022-01-28 06:49:30
@article{1f9ee324-cb82-4a57-94d3-22d2d2da3c28, abstract = {{The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p < 0.001). Pregnant patients with sight-threatening deterioration of retinopathy had higher HbA1c levels than those without (p = 0.028 and the decrement in HbA1c between the 6-14th and the 20th week of gestation was more pronounced (p = 0.006). In those patients who developed pre-eclampsia during pregnancy, deterioration of retinopathy ocurred more frequently compared to those without pre-eclampsia (4/8 vs 5/65; p = 0.005). In conclusion, sight-threatening deterioration of retinopathy was not more common during pregnancy in IDDM patients than among age- and duration-matched control patients. In pregnant patients, deterioration of retinopathy was associated with the pregestational degree of metabolic control as well as with a rapidly improved glycaemic control acheived during pregnancy. Among those in whom deterioration occurred during pregnancy, pre-eclampsia was a potent risk factor.}}, author = {{Lövestam Adrian, Monica and Agardh, Carl-David and Åberg, Anders E and Agardh, Elisabet}}, issn = {{1464-5491}}, keywords = {{pre-eclampsia; pregnancy; retinopathy; type 1 diabetes}}, language = {{eng}}, number = {{12}}, pages = {{1059--1065}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Pre-eclampsia is a potent risk factor for deterioration of retinopathy during pregnancy in Type 1 diabetic patients}}, url = {{http://dx.doi.org/10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8}}, doi = {{10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8}}, volume = {{14}}, year = {{1997}}, }