Reference intervals for reticulocyte hemoglobin content in healthy infants
(2018) In Pediatric Research 84. p.657-661- Abstract
Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Methods: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48–72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He. Results: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1–37.7 pg/L (N = 253) at 48–72 h, 25.6–33.4 pg/L (N =... (More)
Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Methods: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48–72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He. Results: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1–37.7 pg/L (N = 253) at 48–72 h, 25.6–33.4 pg/L (N = 341) at four months and 24.9–34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) −4.2 pg/L (−6.1 to −2.4) and at 12 months mean difference (95% CI) −3.4 pg/L (−5.0 to −1.8). Conclusions: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.
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- author
- Löfving, Anders ; Domellöf, Magnus ; Hellström-Westas, Lena LU and Andersson, Ola LU
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- in
- Pediatric Research
- volume
- 84
- pages
- 657 - 661
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- pmid:30140071
- scopus:85053192334
- ISSN
- 0031-3998
- DOI
- 10.1038/s41390-018-0046-4
- language
- English
- LU publication?
- no
- id
- 1faf072c-6fcb-4351-bc04-39ed0890d6e6
- date added to LUP
- 2019-03-31 12:19:16
- date last changed
- 2024-08-21 13:24:03
@article{1faf072c-6fcb-4351-bc04-39ed0890d6e6, abstract = {{<p>Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Methods: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48–72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He. Results: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1–37.7 pg/L (N = 253) at 48–72 h, 25.6–33.4 pg/L (N = 341) at four months and 24.9–34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) −4.2 pg/L (−6.1 to −2.4) and at 12 months mean difference (95% CI) −3.4 pg/L (−5.0 to −1.8). Conclusions: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.</p>}}, author = {{Löfving, Anders and Domellöf, Magnus and Hellström-Westas, Lena and Andersson, Ola}}, issn = {{0031-3998}}, language = {{eng}}, pages = {{657--661}}, publisher = {{International Pediatric Foundation Inc.}}, series = {{Pediatric Research}}, title = {{Reference intervals for reticulocyte hemoglobin content in healthy infants}}, url = {{http://dx.doi.org/10.1038/s41390-018-0046-4}}, doi = {{10.1038/s41390-018-0046-4}}, volume = {{84}}, year = {{2018}}, }