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Antiarrhythmic effect of amperozide, a novel psychotropic compound with class III antiarrhythmic properties, on digoxin-induced arrhythmias in the guinea-pig

Höglund, P LU ; Eriksson, M and Christensson, E G (1986) In Journal of Pharmacy and Pharmacology 38(11). p.3-861
Abstract

Amperozide is a novel psychotropic compound with specific effect in limbic brain areas. Preliminary findings have also indicated an antiarrhythmic effect in-vitro. Injections of saline, amperozide, melperone, thioridazine, bretylium or lignocaine, were given i.p. to anaesthetized guinea-pigs, which 10 min later were given digoxin s.c. to induce arrhythmia. In a series of control experiments none of these compounds caused arrhythmia in combination with the vehicle of digoxin. The time to arrhythmia was significantly prolonged after treatment with amperozide, melperone and bretylium compared with saline, but there were no differences between the treatments. The digoxin concentrations in plasma at death varied considerably within the... (More)

Amperozide is a novel psychotropic compound with specific effect in limbic brain areas. Preliminary findings have also indicated an antiarrhythmic effect in-vitro. Injections of saline, amperozide, melperone, thioridazine, bretylium or lignocaine, were given i.p. to anaesthetized guinea-pigs, which 10 min later were given digoxin s.c. to induce arrhythmia. In a series of control experiments none of these compounds caused arrhythmia in combination with the vehicle of digoxin. The time to arrhythmia was significantly prolonged after treatment with amperozide, melperone and bretylium compared with saline, but there were no differences between the treatments. The digoxin concentrations in plasma at death varied considerably within the groups and no statistical significance was found.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Digoxin, Guinea Pigs, Iodine Radioisotopes, Male, Piperazines, Journal Article
in
Journal of Pharmacy and Pharmacology
volume
38
issue
11
pages
3 - 861
publisher
Pharmaceutical Press
external identifiers
  • scopus:0023022371
ISSN
0022-3573
DOI
10.1111/j.2042-7158.1986.tb04514.x
language
English
LU publication?
yes
id
1fdf9b7f-ca04-4e82-ac18-69baf7e865fc
date added to LUP
2017-09-14 23:43:27
date last changed
2017-09-18 16:31:30
@article{1fdf9b7f-ca04-4e82-ac18-69baf7e865fc,
  abstract     = {<p>Amperozide is a novel psychotropic compound with specific effect in limbic brain areas. Preliminary findings have also indicated an antiarrhythmic effect in-vitro. Injections of saline, amperozide, melperone, thioridazine, bretylium or lignocaine, were given i.p. to anaesthetized guinea-pigs, which 10 min later were given digoxin s.c. to induce arrhythmia. In a series of control experiments none of these compounds caused arrhythmia in combination with the vehicle of digoxin. The time to arrhythmia was significantly prolonged after treatment with amperozide, melperone and bretylium compared with saline, but there were no differences between the treatments. The digoxin concentrations in plasma at death varied considerably within the groups and no statistical significance was found.</p>},
  author       = {Höglund, P and Eriksson, M and Christensson, E G},
  issn         = {0022-3573},
  keyword      = {Animals,Anti-Arrhythmia Agents,Arrhythmias, Cardiac,Digoxin,Guinea Pigs,Iodine Radioisotopes,Male,Piperazines,Journal Article},
  language     = {eng},
  number       = {11},
  pages        = {3--861},
  publisher    = {Pharmaceutical Press},
  series       = {Journal of Pharmacy and Pharmacology},
  title        = {Antiarrhythmic effect of amperozide, a novel psychotropic compound with class III antiarrhythmic properties, on digoxin-induced arrhythmias in the guinea-pig},
  url          = {http://dx.doi.org/10.1111/j.2042-7158.1986.tb04514.x},
  volume       = {38},
  year         = {1986},
}