Hormonemate, a new cytotoxic and apoptosis-inducing compound from the endophytic fungus Hormonema dematioides. I. Identification of the producing strain, and isolation and biological properties of hormonemate
(2003) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 58(7-8). p.547-552- Abstract
- In a search for new fungal compounds inducing apoptosis of the colon cancer derived cell line COLO-320, hormonemate (1) was purified from fermentations of an endophytic fungus isolated from living needles of a Pinus species. The producing strain was identified as Hormonema dematioides by microscopy and ITS rDNA sequence analysis. The structure of hormonemate was determined by spectroscopic methods. The compound exhibited cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 as well as five other human cell lines (HL-60, JURKAT, HEP-G2, MCF-7, HeLa S3). It also induced apoptosis in COLO-320 cells as detected by a caspase-activity assay and morphological changes, and it triggered morphological and physiological... (More)
- In a search for new fungal compounds inducing apoptosis of the colon cancer derived cell line COLO-320, hormonemate (1) was purified from fermentations of an endophytic fungus isolated from living needles of a Pinus species. The producing strain was identified as Hormonema dematioides by microscopy and ITS rDNA sequence analysis. The structure of hormonemate was determined by spectroscopic methods. The compound exhibited cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 as well as five other human cell lines (HL-60, JURKAT, HEP-G2, MCF-7, HeLa S3). It also induced apoptosis in COLO-320 cells as detected by a caspase-activity assay and morphological changes, and it triggered morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently died by apoptosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/301542
- author
- Filip, P ; Weber, RWS ; Sterner, Olov LU and Anke, T
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hormonemate, endophyte, Hormonema dematioides
- in
- Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
- volume
- 58
- issue
- 7-8
- pages
- 547 - 552
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- wos:000185144500017
- scopus:0042156720
- ISSN
- 0939-5075
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 1fe98788-05f0-484a-be2a-f3a64d4ab455 (old id 301542)
- alternative location
- http://www.znaturforsch.com/ac/v58c/c58c.htm#No7
- date added to LUP
- 2016-04-01 17:02:52
- date last changed
- 2022-02-13 02:21:35
@article{1fe98788-05f0-484a-be2a-f3a64d4ab455, abstract = {{In a search for new fungal compounds inducing apoptosis of the colon cancer derived cell line COLO-320, hormonemate (1) was purified from fermentations of an endophytic fungus isolated from living needles of a Pinus species. The producing strain was identified as Hormonema dematioides by microscopy and ITS rDNA sequence analysis. The structure of hormonemate was determined by spectroscopic methods. The compound exhibited cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 as well as five other human cell lines (HL-60, JURKAT, HEP-G2, MCF-7, HeLa S3). It also induced apoptosis in COLO-320 cells as detected by a caspase-activity assay and morphological changes, and it triggered morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently died by apoptosis.}}, author = {{Filip, P and Weber, RWS and Sterner, Olov and Anke, T}}, issn = {{0939-5075}}, keywords = {{hormonemate; endophyte; Hormonema dematioides}}, language = {{eng}}, number = {{7-8}}, pages = {{547--552}}, publisher = {{Verlag der Zeitschrift für Naturforschung}}, series = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}}, title = {{Hormonemate, a new cytotoxic and apoptosis-inducing compound from the endophytic fungus Hormonema dematioides. I. Identification of the producing strain, and isolation and biological properties of hormonemate}}, url = {{http://www.znaturforsch.com/ac/v58c/c58c.htm#No7}}, volume = {{58}}, year = {{2003}}, }