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Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion

Papadakos, Konstantinos S. LU orcid ; Lundgren, Sebastian LU ; Gialeli, Chrysostomi LU ; Micke, Patrick ; Mezheyeuski, Artur ; Elebro, Jacob LU ; Jirström, Karin LU orcid and Blom, Anna M. LU orcid (2022) In OncoImmunology 11(1).
Abstract

Cartilage oligomeric matrix protein (COMP) is an emerging regulator of tumor progression. The aim of this study was to evaluate the expression of COMP in periampullary adenocarcinoma with respect to prognostic value for survival and relapse, levels of fibrosis and infiltrating immune cells. COMP expression was evaluated using immunohistochemistry in primary tumors and subsets of paired lymph node metastases in tissue microarrays including 175 patients with periampullary adenocarcinoma. Collagen content was assessed with Sirius Red-Fast Green staining. High COMP levels were detected in cancer cells and in stroma, in 46% and 57% of the patients, respectively. High COMP expression was strongly associated with more aggressive... (More)

Cartilage oligomeric matrix protein (COMP) is an emerging regulator of tumor progression. The aim of this study was to evaluate the expression of COMP in periampullary adenocarcinoma with respect to prognostic value for survival and relapse, levels of fibrosis and infiltrating immune cells. COMP expression was evaluated using immunohistochemistry in primary tumors and subsets of paired lymph node metastases in tissue microarrays including 175 patients with periampullary adenocarcinoma. Collagen content was assessed with Sirius Red-Fast Green staining. High COMP levels were detected in cancer cells and in stroma, in 46% and 57% of the patients, respectively. High COMP expression was strongly associated with more aggressive pancreatobiliary-type (PB-type) compared to intestinal-type tumors (p < .0001). Importantly, high expression of COMP correlated with the exclusion of cytotoxic T-cells from the cancer cell compartment of the tumors, particularly in PB-type tumors. Higher levels of fibrosis measured by the density of collagen fibers correlated with high COMP levels in both cancer cells and stroma. This in turn could lead to exclusion of cytotoxic T-cells from accessing the cancer cells, a recognized immunotherapy resistance mechanism. Targeting COMP could therefore be considered as a novel therapeutic strategy in PB-type periampullary adenocarcinoma.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
collagen, COMP, fibrosis, immune cell exclusion, pancreatic cancer
in
OncoImmunology
volume
11
issue
1
article number
2111906
publisher
Landes Bioscience
external identifiers
  • pmid:35990519
  • scopus:85136485814
ISSN
2162-4011
DOI
10.1080/2162402X.2022.2111906
language
English
LU publication?
yes
id
1ffa52ce-62db-4142-8eab-fc2e5dcb1dff
date added to LUP
2022-12-28 15:48:35
date last changed
2024-04-18 20:26:15
@article{1ffa52ce-62db-4142-8eab-fc2e5dcb1dff,
  abstract     = {{<p>Cartilage oligomeric matrix protein (COMP) is an emerging regulator of tumor progression. The aim of this study was to evaluate the expression of COMP in periampullary adenocarcinoma with respect to prognostic value for survival and relapse, levels of fibrosis and infiltrating immune cells. COMP expression was evaluated using immunohistochemistry in primary tumors and subsets of paired lymph node metastases in tissue microarrays including 175 patients with periampullary adenocarcinoma. Collagen content was assessed with Sirius Red-Fast Green staining. High COMP levels were detected in cancer cells and in stroma, in 46% and 57% of the patients, respectively. High COMP expression was strongly associated with more aggressive pancreatobiliary-type (PB-type) compared to intestinal-type tumors (p &lt; .0001). Importantly, high expression of COMP correlated with the exclusion of cytotoxic T-cells from the cancer cell compartment of the tumors, particularly in PB-type tumors. Higher levels of fibrosis measured by the density of collagen fibers correlated with high COMP levels in both cancer cells and stroma. This in turn could lead to exclusion of cytotoxic T-cells from accessing the cancer cells, a recognized immunotherapy resistance mechanism. Targeting COMP could therefore be considered as a novel therapeutic strategy in PB-type periampullary adenocarcinoma.</p>}},
  author       = {{Papadakos, Konstantinos S. and Lundgren, Sebastian and Gialeli, Chrysostomi and Micke, Patrick and Mezheyeuski, Artur and Elebro, Jacob and Jirström, Karin and Blom, Anna M.}},
  issn         = {{2162-4011}},
  keywords     = {{collagen; COMP; fibrosis; immune cell exclusion; pancreatic cancer}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Landes Bioscience}},
  series       = {{OncoImmunology}},
  title        = {{Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion}},
  url          = {{http://dx.doi.org/10.1080/2162402X.2022.2111906}},
  doi          = {{10.1080/2162402X.2022.2111906}},
  volume       = {{11}},
  year         = {{2022}},
}