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TFAP2B-Dietary protein and glycemic index interactions and weight maintenance after weight loss in the diogenes trial

Stocks, Tanja LU ; Ängquist, Lars ; Hager, Jörg ; Charon, Celine ; Holst, Claus ; Martinez, J. Alfredo ; Saris, Wim H.M. ; Astrup, Arne ; Sørensen, Thorkild I.A. and Larsen, Lesli H. (2013) In Human Heredity 75(2-4). p.213-219
Abstract

Background:TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has an effect on weight loss. We investigated interactions between rs987237 and protein-to-carbohydrate ratio or glycemic index (GI) in relation to weight maintenance after weight loss. Methods: This study included 742 obese individuals from 8 European countries who participated in the Diet, Obesity, and Genes (DiOGenes) trial, lost ≥8% of their initial body weight during an 8-week low-calorie diet and were randomized to one of 5 ad libitum diets with a fixed energy percentage from fat: either low-protein/low-GI, low-protein/high-GI, high-protein/low-GI, or high-protein/high-GI diets, or a control diet for a... (More)

Background:TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has an effect on weight loss. We investigated interactions between rs987237 and protein-to-carbohydrate ratio or glycemic index (GI) in relation to weight maintenance after weight loss. Methods: This study included 742 obese individuals from 8 European countries who participated in the Diet, Obesity, and Genes (DiOGenes) trial, lost ≥8% of their initial body weight during an 8-week low-calorie diet and were randomized to one of 5 ad libitum diets with a fixed energy percentage from fat: either low-protein/low-GI, low-protein/high-GI, high-protein/low-GI, or high-protein/high-GI diets, or a control diet for a 6-month weight maintenance period. Using linear regression analyses and additive genetic models, we investigated main and dietary interaction effects of TFAP2B rs987237 in relation to weight maintenance. Results: In total, 468 completers of the trial were genotyped for rs987237. High-protein diets were beneficial for weight maintenance in the AA genotype group (67% of participants), but in the AG and GG groups no differences were observed for low-or high-protein diets. On the high-protein diet, carriers of the obesity risk allele (G allele) regained 1.84 kg (95% CI: 0.02; 3.67, p = 0.047) more body weight per risk allele than individuals on a low-protein diet. There was no interaction effect between rs987237 and GI on weight maintenance. Conclusion:TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance. Considering the carbohydrate proportion of the diet, the interaction was different from the previously reported rs987237-fat-to-carbohydrate ratio interaction for weight loss. Thus, TFAP2B-macronutrient interactions might diverge depending on the nutritional state.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Body weight changes, Diet, Dietary carbohydrates, Dietary proteins, Glycemic index, Obesity, Transcription factor AP-2 beta
in
Human Heredity
volume
75
issue
2-4
pages
7 pages
publisher
Karger
external identifiers
  • scopus:84884998031
  • pmid:24081236
ISSN
0001-5652
DOI
10.1159/000353591
language
English
LU publication?
no
id
1ffe65ae-e1ea-479b-9784-b7472b38959c
date added to LUP
2019-05-31 08:51:43
date last changed
2019-07-29 15:14:14
@article{1ffe65ae-e1ea-479b-9784-b7472b38959c,
  abstract     = {<p>Background:TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has an effect on weight loss. We investigated interactions between rs987237 and protein-to-carbohydrate ratio or glycemic index (GI) in relation to weight maintenance after weight loss. Methods: This study included 742 obese individuals from 8 European countries who participated in the Diet, Obesity, and Genes (DiOGenes) trial, lost ≥8% of their initial body weight during an 8-week low-calorie diet and were randomized to one of 5 ad libitum diets with a fixed energy percentage from fat: either low-protein/low-GI, low-protein/high-GI, high-protein/low-GI, or high-protein/high-GI diets, or a control diet for a 6-month weight maintenance period. Using linear regression analyses and additive genetic models, we investigated main and dietary interaction effects of TFAP2B rs987237 in relation to weight maintenance. Results: In total, 468 completers of the trial were genotyped for rs987237. High-protein diets were beneficial for weight maintenance in the AA genotype group (67% of participants), but in the AG and GG groups no differences were observed for low-or high-protein diets. On the high-protein diet, carriers of the obesity risk allele (G allele) regained 1.84 kg (95% CI: 0.02; 3.67, p = 0.047) more body weight per risk allele than individuals on a low-protein diet. There was no interaction effect between rs987237 and GI on weight maintenance. Conclusion:TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance. Considering the carbohydrate proportion of the diet, the interaction was different from the previously reported rs987237-fat-to-carbohydrate ratio interaction for weight loss. Thus, TFAP2B-macronutrient interactions might diverge depending on the nutritional state.</p>},
  author       = {Stocks, Tanja and Ängquist, Lars and Hager, Jörg and Charon, Celine and Holst, Claus and Martinez, J. Alfredo and Saris, Wim H.M. and Astrup, Arne and Sørensen, Thorkild I.A. and Larsen, Lesli H.},
  issn         = {0001-5652},
  language     = {eng},
  month        = {01},
  number       = {2-4},
  pages        = {213--219},
  publisher    = {Karger},
  series       = {Human Heredity},
  title        = {TFAP2B-Dietary protein and glycemic index interactions and weight maintenance after weight loss in the diogenes trial},
  url          = {http://dx.doi.org/10.1159/000353591},
  doi          = {10.1159/000353591},
  volume       = {75},
  year         = {2013},
}