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Long-term lead elimination from plasma and whole blood after poisoning.

Rentschler, Gerda LU ; Broberg Palmgren, Karin LU ; Lundh, Thomas LU and Skerfving, Staffan LU (2012) In International Archives of Occupational and Environmental Health 85. p.311-316
Abstract
OBJECTIVE:



Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

METHODS:



A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

RESULTS:



P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

CONCLUSION:



P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Occupational and Environmental Health
volume
85
pages
311 - 316
publisher
Springer
external identifiers
  • wos:000301573400008
  • pmid:21701834
  • scopus:84862699588
ISSN
1432-1246
DOI
10.1007/s00420-011-0673-0
language
English
LU publication?
yes
id
fda68af4-33da-482e-97ad-9a7bb3aff0da (old id 2007777)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21701834?dopt=Abstract
date added to LUP
2011-07-06 11:11:05
date last changed
2017-08-20 04:02:48
@article{fda68af4-33da-482e-97ad-9a7bb3aff0da,
  abstract     = {OBJECTIVE:<br/><br>
<br/><br>
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.<br/><br>
METHODS:<br/><br>
<br/><br>
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.<br/><br>
RESULTS:<br/><br>
<br/><br>
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.<br/><br>
CONCLUSION:<br/><br>
<br/><br>
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.},
  author       = {Rentschler, Gerda and Broberg Palmgren, Karin and Lundh, Thomas and Skerfving, Staffan},
  issn         = {1432-1246},
  language     = {eng},
  pages        = {311--316},
  publisher    = {Springer},
  series       = {International Archives of Occupational and Environmental Health},
  title        = {Long-term lead elimination from plasma and whole blood after poisoning.},
  url          = {http://dx.doi.org/10.1007/s00420-011-0673-0},
  volume       = {85},
  year         = {2012},
}