Long-term lead elimination from plasma and whole blood after poisoning.
(2012) In International Archives of Occupational and Environmental Health 85. p.311-316- Abstract
- OBJECTIVE:
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2007777
- author
- Rentschler, Gerda LU ; Broberg Palmgren, Karin LU ; Lundh, Thomas LU and Skerfving, Staffan LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Archives of Occupational and Environmental Health
- volume
- 85
- pages
- 311 - 316
- publisher
- Springer
- external identifiers
-
- wos:000301573400008
- pmid:21701834
- scopus:84862699588
- pmid:21701834
- ISSN
- 1432-1246
- DOI
- 10.1007/s00420-011-0673-0
- language
- English
- LU publication?
- yes
- id
- fda68af4-33da-482e-97ad-9a7bb3aff0da (old id 2007777)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21701834?dopt=Abstract
- date added to LUP
- 2016-04-01 14:01:54
- date last changed
- 2022-03-29 18:50:27
@article{fda68af4-33da-482e-97ad-9a7bb3aff0da, abstract = {{OBJECTIVE:<br/><br> <br/><br> Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.<br/><br> METHODS:<br/><br> <br/><br> A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.<br/><br> RESULTS:<br/><br> <br/><br> P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.<br/><br> CONCLUSION:<br/><br> <br/><br> P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.}}, author = {{Rentschler, Gerda and Broberg Palmgren, Karin and Lundh, Thomas and Skerfving, Staffan}}, issn = {{1432-1246}}, language = {{eng}}, pages = {{311--316}}, publisher = {{Springer}}, series = {{International Archives of Occupational and Environmental Health}}, title = {{Long-term lead elimination from plasma and whole blood after poisoning.}}, url = {{https://lup.lub.lu.se/search/files/3732587/2173996.pdf}}, doi = {{10.1007/s00420-011-0673-0}}, volume = {{85}}, year = {{2012}}, }