Advanced

Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas.

Carneiro, Ana LU ; Bendahl, Pär-Ola LU ; Åkerman, Måns LU ; Domanski, Henryk LU ; Rydholm, Anders LU ; Engellau, Jacob LU and Nilbert, Mef LU (2011) In Journal of Clinical Pathology 64. p.689-694
Abstract
Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. Results Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment... (More)
Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. Results Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment for surgical margin (HR=2.4, 95% CI 1.4 to 4.3; p=0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR=3.9, p<0.0001) and ezrin and growth pattern (OR=3.1, p=0.03). Conclusions Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcoma patients who would benefit from neoadjuvant therapy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Pathology
volume
64
pages
689 - 694
publisher
BMJ Publishing Group
external identifiers
  • wos:000292916500008
  • pmid:21653656
  • scopus:79960730612
ISSN
1472-4146
DOI
10.1136/jcp.2011.089805
language
English
LU publication?
yes
id
54f2129c-3cdc-4c06-8b1c-7307a1ab3c04 (old id 2008324)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21653656?dopt=Abstract
date added to LUP
2011-07-04 13:25:46
date last changed
2017-03-26 04:29:17
@article{54f2129c-3cdc-4c06-8b1c-7307a1ab3c04,
  abstract     = {Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. Results Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment for surgical margin (HR=2.4, 95% CI 1.4 to 4.3; p=0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR=3.9, p&lt;0.0001) and ezrin and growth pattern (OR=3.1, p=0.03). Conclusions Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcoma patients who would benefit from neoadjuvant therapy.},
  author       = {Carneiro, Ana and Bendahl, Pär-Ola and Åkerman, Måns and Domanski, Henryk and Rydholm, Anders and Engellau, Jacob and Nilbert, Mef},
  issn         = {1472-4146},
  language     = {eng},
  pages        = {689--694},
  publisher    = {BMJ Publishing Group},
  series       = {Journal of Clinical Pathology},
  title        = {Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas.},
  url          = {http://dx.doi.org/10.1136/jcp.2011.089805},
  volume       = {64},
  year         = {2011},
}