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The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-A review.

Fredenberg, Susanne LU ; Wahlgren, Marie LU ; Reslow, Mats and Axelsson, Anders LU (2011) In International Journal of Pharmaceutics 415(1-2). p.34-52
Abstract
Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various... (More)
Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various mechanisms of drug release that have been reported in the literature are analyzed in this review, and practical examples are given. The complexity of drug release from PLGA-based drug delivery systems can make the generalization of results and predictions of drug release difficult. However, this complexity also provides many possible ways of solving problems and modifying drug release. Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Pharmaceutics
volume
415
issue
1-2
pages
34 - 52
publisher
Elsevier
external identifiers
  • wos:000293304900007
  • pmid:21640806
  • scopus:79960154421
ISSN
1873-3476
DOI
10.1016/j.ijpharm.2011.05.049
language
English
LU publication?
yes
id
4ade121a-549c-4d9c-97b8-e6490f392ca1 (old id 2008537)
date added to LUP
2011-07-20 12:03:00
date last changed
2017-11-05 03:03:03
@article{4ade121a-549c-4d9c-97b8-e6490f392ca1,
  abstract     = {Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various mechanisms of drug release that have been reported in the literature are analyzed in this review, and practical examples are given. The complexity of drug release from PLGA-based drug delivery systems can make the generalization of results and predictions of drug release difficult. However, this complexity also provides many possible ways of solving problems and modifying drug release. Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals.},
  author       = {Fredenberg, Susanne and Wahlgren, Marie and Reslow, Mats and Axelsson, Anders},
  issn         = {1873-3476},
  language     = {eng},
  number       = {1-2},
  pages        = {34--52},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-A review.},
  url          = {http://dx.doi.org/10.1016/j.ijpharm.2011.05.049},
  volume       = {415},
  year         = {2011},
}