The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-A review.
Fredenberg, Susanne LU ; Wahlgren, Marie LU
; Reslow, Mats
and Axelsson, Anders
LU
(2011)
In International Journal of Pharmaceutics
415(1-2).
p.34-52
- Abstract
- Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various... (More)
- Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various mechanisms of drug release that have been reported in the literature are analyzed in this review, and practical examples are given. The complexity of drug release from PLGA-based drug delivery systems can make the generalization of results and predictions of drug release difficult. However, this complexity also provides many possible ways of solving problems and modifying drug release. Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008537
- author
- Fredenberg, Susanne
LU
; Wahlgren, Marie
LU
; Reslow, Mats
and Axelsson, Anders
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Pharmaceutics
- volume
- 415
- issue
- 1-2
- pages
- 34 - 52
- publisher
- Elsevier
- external identifiers
-
- wos:000293304900007
- pmid:21640806
- scopus:79960154421
- pmid:21640806
- ISSN
- 1873-3476
- DOI
- 10.1016/j.ijpharm.2011.05.049
- language
- English
- LU publication?
- yes
- id
- 4ade121a-549c-4d9c-97b8-e6490f392ca1 (old id 2008537)
- date added to LUP
- 2016-04-01 09:57:09
- date last changed
- 2023-12-08 04:50:36
@article{4ade121a-549c-4d9c-97b8-e6490f392ca1,
abstract = {{Poly(d,l-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various mechanisms of drug release that have been reported in the literature are analyzed in this review, and practical examples are given. The complexity of drug release from PLGA-based drug delivery systems can make the generalization of results and predictions of drug release difficult. However, this complexity also provides many possible ways of solving problems and modifying drug release. Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals.}},
author = {{Fredenberg, Susanne and Wahlgren, Marie and Reslow, Mats and Axelsson, Anders}},
issn = {{1873-3476}},
language = {{eng}},
number = {{1-2}},
pages = {{34--52}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-A review.}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2011.05.049}},
doi = {{10.1016/j.ijpharm.2011.05.049}},
volume = {{415}},
year = {{2011}},
}