Advanced

The pioneer gut microbiota in human neonates vaginally born at term - a pilot study.

Karlsson, Caroline; Molin, Göran; Cilio, Corrado LU and Ahrné, Siv (2011) In Pediatric Research 70(3). p.282-286
Abstract
The pioneer microbiota of the neonate may affect future actions of the immune system. This study aimed to map the pioneer microbiota in healthy neonates vaginally born at term. A subgroup of neonates born large for gestational age (LGA) was compared with the neonates appropriate for gestational age (AGA). Fecal samples were collected, within 48 hours after birth, from 79 neonates. Quantitative polymerase chain reaction was used for enumeration of Lactobacillus, a subgroup of Lactobacillus common in the vagina, Bifidobacterium, Enterococcus, Enterobacteriaceae and the Bacteroides fragilis group. Cloning and sequencing were applied for subgroups of neonates born LGA or AGA. Lactobacillus was detected in all neonates while other bacterial... (More)
The pioneer microbiota of the neonate may affect future actions of the immune system. This study aimed to map the pioneer microbiota in healthy neonates vaginally born at term. A subgroup of neonates born large for gestational age (LGA) was compared with the neonates appropriate for gestational age (AGA). Fecal samples were collected, within 48 hours after birth, from 79 neonates. Quantitative polymerase chain reaction was used for enumeration of Lactobacillus, a subgroup of Lactobacillus common in the vagina, Bifidobacterium, Enterococcus, Enterobacteriaceae and the Bacteroides fragilis group. Cloning and sequencing were applied for subgroups of neonates born LGA or AGA. Lactobacillus was detected in all neonates while other bacterial groups were detected only in 14-30% of the subjects. The prevalence of Gram-negative Proteobacteria was higher in neonates born LGA while Gram-positive Firmicutes was more prevalent in neonates born AGA (P<.001). This study contributed to increased knowledge of the pioneer microbiota and indicates that neonates born LGA had significantly different microbiota compare to those born AGA. As the early microbiota can be important for maturation of the immune system, the outcome from this study may be relevant in the care of pregnant woman and newborns. LIST OF ABBREVIATIONS:: (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
70
issue
3
pages
282 - 286
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000294192200012
  • pmid:21629156
  • scopus:80051727452
ISSN
1530-0447
DOI
10.1203/PDR.0b013e318225f765
language
English
LU publication?
yes
id
0d451866-2727-40ae-bc75-bb2c7258bd4c (old id 2008621)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21629156?dopt=Abstract
date added to LUP
2011-07-01 11:36:57
date last changed
2017-08-27 03:14:58
@article{0d451866-2727-40ae-bc75-bb2c7258bd4c,
  abstract     = {The pioneer microbiota of the neonate may affect future actions of the immune system. This study aimed to map the pioneer microbiota in healthy neonates vaginally born at term. A subgroup of neonates born large for gestational age (LGA) was compared with the neonates appropriate for gestational age (AGA). Fecal samples were collected, within 48 hours after birth, from 79 neonates. Quantitative polymerase chain reaction was used for enumeration of Lactobacillus, a subgroup of Lactobacillus common in the vagina, Bifidobacterium, Enterococcus, Enterobacteriaceae and the Bacteroides fragilis group. Cloning and sequencing were applied for subgroups of neonates born LGA or AGA. Lactobacillus was detected in all neonates while other bacterial groups were detected only in 14-30% of the subjects. The prevalence of Gram-negative Proteobacteria was higher in neonates born LGA while Gram-positive Firmicutes was more prevalent in neonates born AGA (P&lt;.001). This study contributed to increased knowledge of the pioneer microbiota and indicates that neonates born LGA had significantly different microbiota compare to those born AGA. As the early microbiota can be important for maturation of the immune system, the outcome from this study may be relevant in the care of pregnant woman and newborns. LIST OF ABBREVIATIONS::},
  author       = {Karlsson, Caroline and Molin, Göran and Cilio, Corrado and Ahrné, Siv},
  issn         = {1530-0447},
  language     = {eng},
  number       = {3},
  pages        = {282--286},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {The pioneer gut microbiota in human neonates vaginally born at term - a pilot study.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e318225f765},
  volume       = {70},
  year         = {2011},
}