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Complement deficiency states and associated infections.

Melander Skattum, Lillemor LU ; van Deuren, Marcel; van der Poll, Tom and Truedsson, Lennart LU (2011) In Molecular Immunology 48. p.1643-1655
Abstract
A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for... (More)
A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Immunology
volume
48
pages
1643 - 1655
publisher
Pergamon
external identifiers
  • WOS:000294096100007
  • PMID:21624663
  • Scopus:79960452978
ISSN
1872-9142
DOI
10.1016/j.molimm.2011.05.001
language
English
LU publication?
yes
id
b8e3d045-f0c5-4e68-8ade-f4d0e8a87cff (old id 2008690)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21624663?dopt=Abstract
date added to LUP
2011-07-01 10:58:03
date last changed
2017-02-12 04:23:05
@article{b8e3d045-f0c5-4e68-8ade-f4d0e8a87cff,
  abstract     = {A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed.},
  author       = {Melander Skattum, Lillemor and van Deuren, Marcel and van der Poll, Tom and Truedsson, Lennart},
  issn         = {1872-9142},
  language     = {eng},
  pages        = {1643--1655},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {Complement deficiency states and associated infections.},
  url          = {http://dx.doi.org/10.1016/j.molimm.2011.05.001},
  volume       = {48},
  year         = {2011},
}