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The Human Proteome Project: Current State and Future Direction

Legrain, Pierre; Aebersold, Ruedi; Archakov, Alexander; Bairoch, Amos; Bala, Kumar; Beretta, Laura; Bergeron, John; Borchers, Christoph H.; Corthals, Garry L. and Costello, Catherine E., et al. (2011) In Molecular & Cellular Proteomics 10(7).
Abstract
After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will... (More)
After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators. Molecular & Cellular Proteomics 10: 10.1074/mcp.M111.009993, 1-5, 2011. (Less)
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Molecular & Cellular Proteomics
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10
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7
publisher
American Society for Biochemistry and Molecular Biology
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  • scopus:79960179572
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1535-9484
DOI
10.1074/mcp.M111.009993
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English
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2011-07-25 15:20:05
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@article{d3805113-be46-4b32-97d4-9c61681102e2,
  abstract     = {After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators. Molecular & Cellular Proteomics 10: 10.1074/mcp.M111.009993, 1-5, 2011.},
  author       = {Legrain, Pierre and Aebersold, Ruedi and Archakov, Alexander and Bairoch, Amos and Bala, Kumar and Beretta, Laura and Bergeron, John and Borchers, Christoph H. and Corthals, Garry L. and Costello, Catherine E. and Deutsch, Eric W. and Domon, Bruno and Hancock, William and He, Fuchu and Hochstrasser, Denis and Marko-Varga, György and Salekdeh, Ghasem Hosseini and Sechi, Salvatore and Snyder, Michael and Srivastava, Sudhir and Uhlen, Mathias and Wu, Cathy H. and Yamamoto, Tadashi and Paik, Young-Ki and Omenn, Gilbert S.},
  issn         = {1535-9484},
  language     = {eng},
  number       = {7},
  publisher    = {American Society for Biochemistry and Molecular Biology},
  series       = {Molecular & Cellular Proteomics},
  title        = {The Human Proteome Project: Current State and Future Direction},
  url          = {http://dx.doi.org/10.1074/mcp.M111.009993},
  volume       = {10},
  year         = {2011},
}