Advanced

Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden

Larsson, Anna-Karin A LU ; Gustafsson, Eva LU ; Nilsson, Anna LU ; Odenholt, Inga LU ; Ringberg, Håkan LU and Melander, Eva LU (2011) In Scandinavian Journal of Infectious Diseases 43(6-7). p.456-462
Abstract
Background: The duration of colonization with methicillin-resistant Staphylococcus aureus (MRSA) is not well known and there is debate as to whether a patient colonized with MRSA ever can be defined as 'MRSA-negative'. Methods: Since 2003 all notified MRSA cases have been systematically followed in Skane County, southern Sweden. Cultures are taken from the nares, throat, perineum and possible skin lesions. Contact tracing is conducted. The screening program continues as long as cultures are positive and then until 1 y of consecutive negative cultures for MRSA is completed. Results: Of the 578 MRSA cases during 2003-2006, 535 were included in this retrospective study. The median duration of colonization with MRSA was 5.9 months. Having... (More)
Background: The duration of colonization with methicillin-resistant Staphylococcus aureus (MRSA) is not well known and there is debate as to whether a patient colonized with MRSA ever can be defined as 'MRSA-negative'. Methods: Since 2003 all notified MRSA cases have been systematically followed in Skane County, southern Sweden. Cultures are taken from the nares, throat, perineum and possible skin lesions. Contact tracing is conducted. The screening program continues as long as cultures are positive and then until 1 y of consecutive negative cultures for MRSA is completed. Results: Of the 578 MRSA cases during 2003-2006, 535 were included in this retrospective study. The median duration of colonization with MRSA was 5.9 months. Having household contacts with MRSA, young age, spa-type t002 and colonization in 2 or more locations, were significantly associated with a longer duration of colonization. Having a clinical infection treated with antibiotics (compared to clinical infection with no antibiotic treatment or asymptomatic carriage) was significantly associated with a shorter carriage time. Eradication treatment was associated with a shorter carriage time. Conclusion: These results may have implications for the management of patients with MRSA carriage. The study indicates that MRSA carriage can be defined as 'negative' in a follow-up program and shows the importance of performing contact tracing among household members. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic resistance, MRSA, community associated, risk factor, contact, tracing
in
Scandinavian Journal of Infectious Diseases
volume
43
issue
6-7
pages
456 - 462
publisher
Informa Healthcare
external identifiers
  • wos:000291662600007
  • scopus:79959240699
ISSN
1651-1980
DOI
10.3109/00365548.2011.562530
language
English
LU publication?
yes
id
9b2d23fc-3beb-4e93-b970-b6373fe66714 (old id 2049432)
date added to LUP
2011-08-02 09:01:33
date last changed
2017-05-07 03:55:19
@article{9b2d23fc-3beb-4e93-b970-b6373fe66714,
  abstract     = {Background: The duration of colonization with methicillin-resistant Staphylococcus aureus (MRSA) is not well known and there is debate as to whether a patient colonized with MRSA ever can be defined as 'MRSA-negative'. Methods: Since 2003 all notified MRSA cases have been systematically followed in Skane County, southern Sweden. Cultures are taken from the nares, throat, perineum and possible skin lesions. Contact tracing is conducted. The screening program continues as long as cultures are positive and then until 1 y of consecutive negative cultures for MRSA is completed. Results: Of the 578 MRSA cases during 2003-2006, 535 were included in this retrospective study. The median duration of colonization with MRSA was 5.9 months. Having household contacts with MRSA, young age, spa-type t002 and colonization in 2 or more locations, were significantly associated with a longer duration of colonization. Having a clinical infection treated with antibiotics (compared to clinical infection with no antibiotic treatment or asymptomatic carriage) was significantly associated with a shorter carriage time. Eradication treatment was associated with a shorter carriage time. Conclusion: These results may have implications for the management of patients with MRSA carriage. The study indicates that MRSA carriage can be defined as 'negative' in a follow-up program and shows the importance of performing contact tracing among household members.},
  author       = {Larsson, Anna-Karin A and Gustafsson, Eva and Nilsson, Anna and Odenholt, Inga and Ringberg, Håkan and Melander, Eva},
  issn         = {1651-1980},
  keyword      = {Antibiotic resistance,MRSA,community associated,risk factor,contact,tracing},
  language     = {eng},
  number       = {6-7},
  pages        = {456--462},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden},
  url          = {http://dx.doi.org/10.3109/00365548.2011.562530},
  volume       = {43},
  year         = {2011},
}