Environmental influence on gene expression and recovery from cerebral ischemia
(1999) In Acta Neurochirurgica. Supplementum 73. p.51-55- Abstract
- An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle... (More)
- An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle cerebral artery significantly enhances outcome. Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment. The functional significance of altered gene expression needs to be evaluated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115175
- author
- Johansson, Barbro LU ; Zhao, L and Mattsson, Bengt LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neurochirurgica. Supplementum
- volume
- 73
- pages
- 51 - 55
- publisher
- Springer
- external identifiers
-
- pmid:10494341
- scopus:0032612842
- ISSN
- 0065-1419
- language
- English
- LU publication?
- yes
- id
- 20547a03-b692-4cfd-a486-880eff1eb028 (old id 1115175)
- date added to LUP
- 2016-04-01 16:24:45
- date last changed
- 2022-02-20 05:55:23
@article{20547a03-b692-4cfd-a486-880eff1eb028,
abstract = {{An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle cerebral artery significantly enhances outcome. Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment. The functional significance of altered gene expression needs to be evaluated.}},
author = {{Johansson, Barbro and Zhao, L and Mattsson, Bengt}},
issn = {{0065-1419}},
language = {{eng}},
pages = {{51--55}},
publisher = {{Springer}},
series = {{Acta Neurochirurgica. Supplementum}},
title = {{Environmental influence on gene expression and recovery from cerebral ischemia}},
volume = {{73}},
year = {{1999}},
}