Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.
(2011) In Journal of Experimental Medicine 208(8). p.1563-1570- Abstract
- Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs have been identified, opposing extrinsic repressors of HSC expansion in vivo have yet to be described. Like many other acute and chronic inflammatory diseases, bone marrow (BM) failure syndromes are associated with tumor necrosis factor-α (TNF) overexpression. However, the in vivo relevance of TNF in the regulation of HSCs has remained unclear. Of... (More)
- Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs have been identified, opposing extrinsic repressors of HSC expansion in vivo have yet to be described. Like many other acute and chronic inflammatory diseases, bone marrow (BM) failure syndromes are associated with tumor necrosis factor-α (TNF) overexpression. However, the in vivo relevance of TNF in the regulation of HSCs has remained unclear. Of considerable relevance for normal hematopoiesis and in particular BM failure syndromes, we herein demonstrate that TNF is a cell-extrinsic and potent endogenous suppressor of normal HSC activity in vivo in mice. These effects of TNF involve two distinct TNF receptors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058522
- author
- Pronk, Kees-Jan LU ; Veiby, Ole Petter ; Bryder, David LU and Jacobsen, Sten Eirik W LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Experimental Medicine
- volume
- 208
- issue
- 8
- pages
- 1563 - 1570
- publisher
- Rockefeller University Press
- external identifiers
-
- wos:000293441500001
- pmid:21768269
- scopus:79961138056
- pmid:21768269
- ISSN
- 1540-9538
- DOI
- 10.1084/jem.20110752
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Stem Cell Aging (013212073), Stem Cell Center (013041110)
- id
- 52ba4948-b7c0-4640-970e-a3efbdd65e1b (old id 2058522)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21768269?dopt=Abstract
- date added to LUP
- 2016-04-01 13:00:02
- date last changed
- 2022-07-30 06:36:40
@article{52ba4948-b7c0-4640-970e-a3efbdd65e1b, abstract = {{Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs have been identified, opposing extrinsic repressors of HSC expansion in vivo have yet to be described. Like many other acute and chronic inflammatory diseases, bone marrow (BM) failure syndromes are associated with tumor necrosis factor-α (TNF) overexpression. However, the in vivo relevance of TNF in the regulation of HSCs has remained unclear. Of considerable relevance for normal hematopoiesis and in particular BM failure syndromes, we herein demonstrate that TNF is a cell-extrinsic and potent endogenous suppressor of normal HSC activity in vivo in mice. These effects of TNF involve two distinct TNF receptors.}}, author = {{Pronk, Kees-Jan and Veiby, Ole Petter and Bryder, David and Jacobsen, Sten Eirik W}}, issn = {{1540-9538}}, language = {{eng}}, number = {{8}}, pages = {{1563--1570}}, publisher = {{Rockefeller University Press}}, series = {{Journal of Experimental Medicine}}, title = {{Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.}}, url = {{https://lup.lub.lu.se/search/files/3100149/2220128.pdf}}, doi = {{10.1084/jem.20110752}}, volume = {{208}}, year = {{2011}}, }