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Increased IL-1 beta reactivity upon a glucose challenge in patients with deliberate self-harm

Westling, Sofie LU ; Ahrén, Bo LU ; Träskman Bendz, Lil LU and Brundin, Lena LU (2011) In Acta Psychiatrica Scandinavica 124(4). p.301-306
Abstract
Objective: A disturbed glucose metabolism has been observed in patients with aggressive behaviour. Interleukin (IL)-1β is a pro-inflammatory cytokine that can induce hypoglycaemia, but has also been suggested to be involved in the generation of hostility and aggression. Our group has previously shown an altered glucose metabolism in patients with self-inflicted aggressive behaviour. We investigated the hypothesis that the levels of IL-1 would be increased in these patients, because this might explain the aberrant glucose metabolism and add further knowledge to the aetiology of self-inflicted aggressive behaviour. Method: We investigated plasma cytokine changes in 13 patients with borderline personality disorder and 13 healthy controls... (More)
Objective: A disturbed glucose metabolism has been observed in patients with aggressive behaviour. Interleukin (IL)-1β is a pro-inflammatory cytokine that can induce hypoglycaemia, but has also been suggested to be involved in the generation of hostility and aggression. Our group has previously shown an altered glucose metabolism in patients with self-inflicted aggressive behaviour. We investigated the hypothesis that the levels of IL-1 would be increased in these patients, because this might explain the aberrant glucose metabolism and add further knowledge to the aetiology of self-inflicted aggressive behaviour. Method: We investigated plasma cytokine changes in 13 patients with borderline personality disorder and 13 healthy controls during a 5-h glucose challenge. Plasma samples were analysed for cytokines IL-1β, TNF-α and IL-6 using high-sensitivity multiplex ELISA. Psychiatric symptoms were rated using the Aggression Questionnaire Revised Swedish Version. Results: Basal plasma levels of the three cytokines did not differ between patients and controls. All three cytokines reacted significantly upon the glucose challenge. The increase in IL-1β levels in response to glucose was significantly greater in patients than in controls. Furthermore, IL-1β reactivity was associated with symptoms of hostility. Conclusion: An increased reactivity of IL-1β might be part of a pathogenetic mechanism in patients with deliberate self-harm. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glucose, aggression, IL-1 beta, borderline personality disorder, cytokine
in
Acta Psychiatrica Scandinavica
volume
124
issue
4
pages
301 - 306
publisher
Wiley-Blackwell
external identifiers
  • wos:000294872900008
  • pmid:21762115
  • scopus:80052795028
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2011.01734.x
language
English
LU publication?
yes
id
93c4e9a8-0b03-490c-899d-0e33bd080295 (old id 2058607)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21762115?dopt=Abstract
date added to LUP
2011-08-01 13:08:09
date last changed
2017-08-27 04:36:24
@article{93c4e9a8-0b03-490c-899d-0e33bd080295,
  abstract     = {Objective: A disturbed glucose metabolism has been observed in patients with aggressive behaviour. Interleukin (IL)-1β is a pro-inflammatory cytokine that can induce hypoglycaemia, but has also been suggested to be involved in the generation of hostility and aggression. Our group has previously shown an altered glucose metabolism in patients with self-inflicted aggressive behaviour. We investigated the hypothesis that the levels of IL-1 would be increased in these patients, because this might explain the aberrant glucose metabolism and add further knowledge to the aetiology of self-inflicted aggressive behaviour. Method: We investigated plasma cytokine changes in 13 patients with borderline personality disorder and 13 healthy controls during a 5-h glucose challenge. Plasma samples were analysed for cytokines IL-1β, TNF-α and IL-6 using high-sensitivity multiplex ELISA. Psychiatric symptoms were rated using the Aggression Questionnaire Revised Swedish Version. Results: Basal plasma levels of the three cytokines did not differ between patients and controls. All three cytokines reacted significantly upon the glucose challenge. The increase in IL-1β levels in response to glucose was significantly greater in patients than in controls. Furthermore, IL-1β reactivity was associated with symptoms of hostility. Conclusion: An increased reactivity of IL-1β might be part of a pathogenetic mechanism in patients with deliberate self-harm.},
  author       = {Westling, Sofie and Ahrén, Bo and Träskman Bendz, Lil and Brundin, Lena},
  issn         = {1600-0447},
  keyword      = {glucose,aggression,IL-1 beta,borderline personality disorder,cytokine},
  language     = {eng},
  number       = {4},
  pages        = {301--306},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Increased IL-1 beta reactivity upon a glucose challenge in patients with deliberate self-harm},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2011.01734.x},
  volume       = {124},
  year         = {2011},
}