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Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden.

Zöller, Bengt LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2011) In European Heart Journal 32. p.2800-2805
Abstract
Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and results Data from the Swedish Multigeneration Register for subjects aged 0-76 years old for the period 1964-2008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two ways: risk of CHD in offspring whose parents had been diagnosed with VTE, and risk of VTE in offspring whose parents had been diagnosed with CHD. The analyses were repeated separately for siblings and spouses. In total, 174 768 offspring had CHD and 56 302 VTE. No association between VTE and CHD was observed among siblings. Among offspring, a... (More)
Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and results Data from the Swedish Multigeneration Register for subjects aged 0-76 years old for the period 1964-2008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two ways: risk of CHD in offspring whose parents had been diagnosed with VTE, and risk of VTE in offspring whose parents had been diagnosed with CHD. The analyses were repeated separately for siblings and spouses. In total, 174 768 offspring had CHD and 56 302 VTE. No association between VTE and CHD was observed among siblings. Among offspring, a lower risk of CHD was observed in subjects whose parents had suffered from VTE [standardized incidence ratio (SIR) 0.94 (95% confidence interval (CI) 0.92-0.95)], while offspring of parents with CHD had an increased risk of VTE [SIR 1.03 (95% CI 1.01-1.04)]. In spouses of VTE patients, an increased risk of CHD was observed [SIR 1.02 (95% CI 1.01-1.03)]. Conversely, risk of VTE was increased among spouses of CHD patients [SIR 1.03 (95% CI 1.02-1.03)]. Subanalyses of cases of myocardial infarction and pulmonary embolism/deep venous thrombosis showed similar results. Conclusion The familial background of CHD is different from that of VTE. The present study suggests that it is unlikely that shared disease-causing mutations exist to a large extent in the population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal
volume
32
pages
2800 - 2805
publisher
Oxford University Press
external identifiers
  • WOS:000297273500020
  • PMID:21750095
  • Scopus:81855168407
ISSN
1522-9645
DOI
10.1093/eurheartj/ehr223
language
English
LU publication?
yes
id
fb3ef214-8fe9-4259-8054-04f8dab540ba (old id 2058698)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21750095?dopt=Abstract
date added to LUP
2011-08-01 13:34:30
date last changed
2017-01-01 07:43:58
@article{fb3ef214-8fe9-4259-8054-04f8dab540ba,
  abstract     = {Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and results Data from the Swedish Multigeneration Register for subjects aged 0-76 years old for the period 1964-2008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two ways: risk of CHD in offspring whose parents had been diagnosed with VTE, and risk of VTE in offspring whose parents had been diagnosed with CHD. The analyses were repeated separately for siblings and spouses. In total, 174 768 offspring had CHD and 56 302 VTE. No association between VTE and CHD was observed among siblings. Among offspring, a lower risk of CHD was observed in subjects whose parents had suffered from VTE [standardized incidence ratio (SIR) 0.94 (95% confidence interval (CI) 0.92-0.95)], while offspring of parents with CHD had an increased risk of VTE [SIR 1.03 (95% CI 1.01-1.04)]. In spouses of VTE patients, an increased risk of CHD was observed [SIR 1.02 (95% CI 1.01-1.03)]. Conversely, risk of VTE was increased among spouses of CHD patients [SIR 1.03 (95% CI 1.02-1.03)]. Subanalyses of cases of myocardial infarction and pulmonary embolism/deep venous thrombosis showed similar results. Conclusion The familial background of CHD is different from that of VTE. The present study suggests that it is unlikely that shared disease-causing mutations exist to a large extent in the population.},
  author       = {Zöller, Bengt and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1522-9645},
  language     = {eng},
  pages        = {2800--2805},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden.},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehr223},
  volume       = {32},
  year         = {2011},
}