Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.
(2011) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 119(8). p.487-497- Abstract
- For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic... (More)
- For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058709
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 119
- issue
- 8
- pages
- 487 - 497
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000292648700001
- pmid:21749448
- scopus:79960283842
- pmid:21749448
- ISSN
- 1600-0463
- DOI
- 10.1111/j.1600-0463.2011.02763.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Virology (013212007), Division of Medical Microbiology (013250400)
- id
- 3f5de162-9853-43c2-9095-0f08b9927f17 (old id 2058709)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21749448?dopt=Abstract
- date added to LUP
- 2016-04-04 08:16:50
- date last changed
- 2022-01-29 03:16:03
@article{3f5de162-9853-43c2-9095-0f08b9927f17, abstract = {{For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.}}, author = {{Vinner, Lasse and Holmgren, Birgitta G and Jensen, Kristoffer J and Esbjörnsson, Joakim and Borggren, Marie and Hentze, Julie L and Karlsson, Ingrid and Andresen, Betina S and Gram, Gregers J and Kloverpris, Henrik and Aaby, Peter and DA Silva, Zacarias Jose and Fenyö, Eva Maria and Fomsgaard, Anders}}, issn = {{1600-0463}}, language = {{eng}}, number = {{8}}, pages = {{487--497}}, publisher = {{John Wiley & Sons Inc.}}, series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}}, title = {{Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.}}, url = {{http://dx.doi.org/10.1111/j.1600-0463.2011.02763.x}}, doi = {{10.1111/j.1600-0463.2011.02763.x}}, volume = {{119}}, year = {{2011}}, }