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Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.

Vinner, Lasse ; Holmgren, Birgitta G LU ; Jensen, Kristoffer J ; Esbjörnsson, Joakim LU orcid ; Borggren, Marie LU ; Hentze, Julie L ; Karlsson, Ingrid ; Andresen, Betina S ; Gram, Gregers J and Kloverpris, Henrik , et al. (2011) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 119(8). p.487-497
Abstract
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic... (More)
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
volume
119
issue
8
pages
487 - 497
publisher
John Wiley and Sons
external identifiers
  • wos:000292648700001
  • pmid:21749448
  • scopus:79960283842
  • pmid:21749448
ISSN
1600-0463
DOI
10.1111/j.1600-0463.2011.02763.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Virology (013212007), Division of Medical Microbiology (013250400)
id
3f5de162-9853-43c2-9095-0f08b9927f17 (old id 2058709)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21749448?dopt=Abstract
date added to LUP
2016-04-04 08:16:50
date last changed
2021-05-25 05:12:48
@article{3f5de162-9853-43c2-9095-0f08b9927f17,
  abstract     = {For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.},
  author       = {Vinner, Lasse and Holmgren, Birgitta G and Jensen, Kristoffer J and Esbjörnsson, Joakim and Borggren, Marie and Hentze, Julie L and Karlsson, Ingrid and Andresen, Betina S and Gram, Gregers J and Kloverpris, Henrik and Aaby, Peter and DA Silva, Zacarias Jose and Fenyö, Eva Maria and Fomsgaard, Anders},
  issn         = {1600-0463},
  language     = {eng},
  number       = {8},
  pages        = {487--497},
  publisher    = {John Wiley and Sons},
  series       = {APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  title        = {Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.},
  url          = {http://dx.doi.org/10.1111/j.1600-0463.2011.02763.x},
  doi          = {10.1111/j.1600-0463.2011.02763.x},
  volume       = {119},
  year         = {2011},
}