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Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.

Vinner, Lasse; Holmgren, Birgitta G LU ; Jensen, Kristoffer J; Esbjörnsson, Joakim LU ; Borggren, Marie LU ; Hentze, Julie L; Karlsson, Ingrid; Andresen, Betina S; Gram, Gregers J and Kloverpris, Henrik, et al. (2011) In Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 119(8). p.487-497
Abstract
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic... (More)
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations. (Less)
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publication status
published
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in
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
volume
119
issue
8
pages
487 - 497
publisher
John Wiley & Sons
external identifiers
  • wos:000292648700001
  • pmid:21749448
  • scopus:79960283842
ISSN
1600-0463
DOI
10.1111/j.1600-0463.2011.02763.x
language
English
LU publication?
yes
id
3f5de162-9853-43c2-9095-0f08b9927f17 (old id 2058709)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21749448?dopt=Abstract
date added to LUP
2011-08-01 13:51:58
date last changed
2017-01-01 07:36:02
@article{3f5de162-9853-43c2-9095-0f08b9927f17,
  abstract     = {For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.},
  author       = {Vinner, Lasse and Holmgren, Birgitta G and Jensen, Kristoffer J and Esbjörnsson, Joakim and Borggren, Marie and Hentze, Julie L and Karlsson, Ingrid and Andresen, Betina S and Gram, Gregers J and Kloverpris, Henrik and Aaby, Peter and DA Silva, Zacarias Jose and Fenyö, Eva Maria and Fomsgaard, Anders},
  issn         = {1600-0463},
  language     = {eng},
  number       = {8},
  pages        = {487--497},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)},
  title        = {Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.},
  url          = {http://dx.doi.org/10.1111/j.1600-0463.2011.02763.x},
  volume       = {119},
  year         = {2011},
}