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Third-trimester conditional reference values for longitudinal fetal growth assessment

Basuki, Tri Rahmat; Triunfo, Stefania; Caradeux, Javier; Eixarch, Elisenda; Hansson, Stefan LU ; Gratacos, Eduard and Figueras, Francesc (2018) In Fetal Diagnosis and Therapy 43(1). p.34-39
Abstract

Objectives: The aim of this study was to derive longitudinal reference values of fetal growth (estimated fetal weight [EFW] and abdominal circumference [AC]) during the third trimester and to develop coefficients for conditional growth assessment. Patients and Methods: A prospective cohort study was conducted involving consecutive singleton pregnancies in a low-risk population for a routine third-trimester scan at 30+0-34+6 weeks and follow-up at 37+0-38+6 weeks for an additional ultrasound. Statistical analysis was based on multilevel modeling using MLwiN software. Unconditional centiles were calculated from z-values at each gestational age, and conditional centiles were calculated from... (More)

Objectives: The aim of this study was to derive longitudinal reference values of fetal growth (estimated fetal weight [EFW] and abdominal circumference [AC]) during the third trimester and to develop coefficients for conditional growth assessment. Patients and Methods: A prospective cohort study was conducted involving consecutive singleton pregnancies in a low-risk population for a routine third-trimester scan at 30+0-34+6 weeks and follow-up at 37+0-38+6 weeks for an additional ultrasound. Statistical analysis was based on multilevel modeling using MLwiN software. Unconditional centiles were calculated from z-values at each gestational age, and conditional centiles were calculated from z-values at a given measurement (30-34 weeks) and the expected measurement (37-38 weeks). Results: At 30-34 weeks, 8 and 9.3% of the fetuses had an unconditional EFW below the 10th and above the 90th centile, respectively. At 37-38 weeks, these figures were 10.3 and 9.3%, respectively. Regarding the unconditional AC, at the first scan, 8.9 and 9.6% had values below the 10th and above the 90th centile, while at the second scan 10.5 and 10.5% had values below the 10th and above the 90th centile, respectively. The proportion with a conditional EFW below the 10th and above the 90th centile was 10.2 and 9.4% at the second scan, respectively. For conditional AC, these figures were 10.7 and 10.3%, respectively. Conclusion: We have produced reference centiles for EFW and AC growth during the third trimester as a useful tool for quantifying growth.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Abdominal circumference, Conditional reference values, Estimated fetal weight, Gestational age, Longitudinal study, Multilevel modeling
in
Fetal Diagnosis and Therapy
volume
43
issue
1
pages
6 pages
publisher
Karger
external identifiers
  • scopus:85040566845
  • pmid:28601881
ISSN
1015-3837
DOI
language
English
LU publication?
yes
id
205b42f5-81a1-44a7-9753-fe8b68ec601f
date added to LUP
2018-02-05 11:23:09
date last changed
2018-05-29 09:19:16
@article{205b42f5-81a1-44a7-9753-fe8b68ec601f,
  abstract     = {<p>Objectives: The aim of this study was to derive longitudinal reference values of fetal growth (estimated fetal weight [EFW] and abdominal circumference [AC]) during the third trimester and to develop coefficients for conditional growth assessment. Patients and Methods: A prospective cohort study was conducted involving consecutive singleton pregnancies in a low-risk population for a routine third-trimester scan at 30<sup>+0</sup>-34<sup>+6</sup> weeks and follow-up at 37<sup>+0</sup>-38<sup>+6</sup> weeks for an additional ultrasound. Statistical analysis was based on multilevel modeling using MLwiN software. Unconditional centiles were calculated from z-values at each gestational age, and conditional centiles were calculated from z-values at a given measurement (30-34 weeks) and the expected measurement (37-38 weeks). Results: At 30-34 weeks, 8 and 9.3% of the fetuses had an unconditional EFW below the 10th and above the 90th centile, respectively. At 37-38 weeks, these figures were 10.3 and 9.3%, respectively. Regarding the unconditional AC, at the first scan, 8.9 and 9.6% had values below the 10th and above the 90th centile, while at the second scan 10.5 and 10.5% had values below the 10th and above the 90th centile, respectively. The proportion with a conditional EFW below the 10th and above the 90th centile was 10.2 and 9.4% at the second scan, respectively. For conditional AC, these figures were 10.7 and 10.3%, respectively. Conclusion: We have produced reference centiles for EFW and AC growth during the third trimester as a useful tool for quantifying growth.</p>},
  author       = {Basuki, Tri Rahmat and Triunfo, Stefania and Caradeux, Javier and Eixarch, Elisenda and Hansson, Stefan and Gratacos, Eduard and Figueras, Francesc},
  issn         = {1015-3837},
  keyword      = {Abdominal circumference,Conditional reference values,Estimated fetal weight,Gestational age,Longitudinal study,Multilevel modeling},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {34--39},
  publisher    = {Karger},
  series       = {Fetal Diagnosis and Therapy},
  title        = {Third-trimester conditional reference values for longitudinal fetal growth assessment},
  url          = {http://dx.doi.org/},
  volume       = {43},
  year         = {2018},
}