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Risk Factors for Nursing Home Placement in Cholinesterase Inhibitor Treated Naturalistic Alzheimer Patients.

Wattmo, Carina LU ; Wallin, Åsa LU and Minthon, Lennart LU (2009) 9th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD)
Abstract
Aims: To analyse which factors influence nursing home placement (NHP) and time until NHP in long-term cholinesterase inhibitor treated patients with Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, on-going, non-randomized, multicentre study in a routine clinical setting. Patients with the diagnosis of AD, living at home at the time of inclusion, receive treatment with donepezil, rivastigmine or galantamine. They are assessed with MMSE, ADAS-cog, IADL and PSMS at baseline and every 6 months over the course of 3 years. The first 883 subjects that had the opportunity to complete the full study were investigated concerning NHP; 210 of these patients were admitted to nursing homes. The following risk... (More)
Aims: To analyse which factors influence nursing home placement (NHP) and time until NHP in long-term cholinesterase inhibitor treated patients with Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, on-going, non-randomized, multicentre study in a routine clinical setting. Patients with the diagnosis of AD, living at home at the time of inclusion, receive treatment with donepezil, rivastigmine or galantamine. They are assessed with MMSE, ADAS-cog, IADL and PSMS at baseline and every 6 months over the course of 3 years. The first 883 subjects that had the opportunity to complete the full study were investigated concerning NHP; 210 of these patients were admitted to nursing homes. The following risk factors for the event NHP (Chi-square and T-tests) and the time until NHP (Cox regression) were investigated: gender, APOE e4-carrier, living alone or with spouse, education level, age, illness duration, cognitive and functional level at baseline and decline in cognition and function prior to NHP. Results: Females (p=0.002), patients living alone (p<0.001), older age (p=0.002), longer illness duration (p=0.004) and lower cognitive and functional status at baseline (p<0.001) are risk factors for admission to a nursing home. The distribution of time until NHP was significantly affected by gender (p=0.048), living alone (p<0.001) and MMSE and IADL score at baseline (p<0.001). Conclusions: Female gender, patients living alone and lower cognitive or functional ability at baseline demonstrated larger risk of early NHP. Cognitive or functional decline prior to NHP did not influence time until NHP. (Less)
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9th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD)
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English
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c53ac1cd-b454-477c-ae27-5fa44145c04c (old id 2064205)
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2011-11-16 13:43:44
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@misc{c53ac1cd-b454-477c-ae27-5fa44145c04c,
  abstract     = {Aims: To analyse which factors influence nursing home placement (NHP) and time until NHP in long-term cholinesterase inhibitor treated patients with Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, on-going, non-randomized, multicentre study in a routine clinical setting. Patients with the diagnosis of AD, living at home at the time of inclusion, receive treatment with donepezil, rivastigmine or galantamine. They are assessed with MMSE, ADAS-cog, IADL and PSMS at baseline and every 6 months over the course of 3 years. The first 883 subjects that had the opportunity to complete the full study were investigated concerning NHP; 210 of these patients were admitted to nursing homes. The following risk factors for the event NHP (Chi-square and T-tests) and the time until NHP (Cox regression) were investigated: gender, APOE e4-carrier, living alone or with spouse, education level, age, illness duration, cognitive and functional level at baseline and decline in cognition and function prior to NHP. Results: Females (p=0.002), patients living alone (p&lt;0.001), older age (p=0.002), longer illness duration (p=0.004) and lower cognitive and functional status at baseline (p&lt;0.001) are risk factors for admission to a nursing home. The distribution of time until NHP was significantly affected by gender (p=0.048), living alone (p&lt;0.001) and MMSE and IADL score at baseline (p&lt;0.001). Conclusions: Female gender, patients living alone and lower cognitive or functional ability at baseline demonstrated larger risk of early NHP. Cognitive or functional decline prior to NHP did not influence time until NHP.},
  author       = {Wattmo, Carina and Wallin, Åsa and Minthon, Lennart},
  language     = {eng},
  title        = {Risk Factors for Nursing Home Placement in Cholinesterase Inhibitor Treated Naturalistic Alzheimer Patients.},
  year         = {2009},
}