Human immunoglobulin G levels of viruses and associated glioma risk
(2011) In Cancer Causes and Control 22(9). p.1259-1266- Abstract
- Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including... (More)
- Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2072397
- author
- Sjostrom, Sara ; Hjalmars, Ulf ; Juto, Per ; Wadell, Goran ; Hallmans, Goran ; Tjonneland, Anne ; Halkjaer, Jytte ; Manjer, Jonas LU ; Almquist, Martin LU and Melin, Beatrice S.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glioma, Glioblastoma, Immunoglobulin G, Virus, Case-control study
- in
- Cancer Causes and Control
- volume
- 22
- issue
- 9
- pages
- 1259 - 1266
- publisher
- Springer
- external identifiers
-
- wos:000293296200004
- scopus:80052306232
- ISSN
- 1573-7225
- DOI
- 10.1007/s10552-011-9799-3
- language
- English
- LU publication?
- yes
- id
- ab5be44c-e4cc-48af-aa94-7768a8943bac (old id 2072397)
- date added to LUP
- 2016-04-01 10:30:22
- date last changed
- 2022-03-27 08:56:05
@article{ab5be44c-e4cc-48af-aa94-7768a8943bac, abstract = {{Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus.}}, author = {{Sjostrom, Sara and Hjalmars, Ulf and Juto, Per and Wadell, Goran and Hallmans, Goran and Tjonneland, Anne and Halkjaer, Jytte and Manjer, Jonas and Almquist, Martin and Melin, Beatrice S.}}, issn = {{1573-7225}}, keywords = {{Glioma; Glioblastoma; Immunoglobulin G; Virus; Case-control study}}, language = {{eng}}, number = {{9}}, pages = {{1259--1266}}, publisher = {{Springer}}, series = {{Cancer Causes and Control}}, title = {{Human immunoglobulin G levels of viruses and associated glioma risk}}, url = {{http://dx.doi.org/10.1007/s10552-011-9799-3}}, doi = {{10.1007/s10552-011-9799-3}}, volume = {{22}}, year = {{2011}}, }