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Brain temperature in volunteers subjected to intranasal cooling

Covaciu, L.; Weis, J.; Bengtsson, C; Allers, M.; Lunderquist, Anders LU ; Ahlstrom, H. and Rubertsson, S. (2011) In Intensive Care Medicine 37(8). p.1277-1284
Abstract
Intranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods. Intranasal balloons catheters circulated with saline at 20A degrees C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured... (More)
Intranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods. Intranasal balloons catheters circulated with saline at 20A degrees C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured before and after the cooling. Mini Mental State Examination (MMSE) test and nasal inspection were done before and after the cooling. Questionnaires about the subjects' personal experience were completed after the experiment. Brain temperature decrease measured by MRSI was -1.7 +/- A 0.8A degrees C and by phase-mapping -1.8 +/- A 0.9A degrees C (n = 9) at the end of cooling. Spatial distribution of temperature changes was relatively uniform. Rectal temperature decreased by -0.5 +/- A 0.3A degrees C (n = 5). The physiological parameters were stable and no shivering was reported. The volunteers remained alert during cooling and no cognitive dysfunctions were apparent in the MMSE test. Postcooling nasal examination detected increased nasal secretion in nine of the ten volunteers. Volunteers' acceptance of the method was good. Both MR techniques revealed brain temperature reductions after 60 min of intranasal cooling with balloons circulated with saline at 20A degrees C in awake, unsedated volunteers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Therapeutic hypothermia, Brain temperature, Magnetic resonance, spectroscopy, Selective brain cooling, Trigeminal reflex
in
Intensive Care Medicine
volume
37
issue
8
pages
1277 - 1284
publisher
Springer
external identifiers
  • wos:000292815000007
  • scopus:79961021453
ISSN
0342-4642
DOI
10.1007/s00134-011-2264-7
language
English
LU publication?
yes
id
5f61f407-9266-4528-bb00-37581a2f3c99 (old id 2091583)
date added to LUP
2011-09-02 08:34:09
date last changed
2017-07-23 03:17:40
@article{5f61f407-9266-4528-bb00-37581a2f3c99,
  abstract     = {Intranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods. Intranasal balloons catheters circulated with saline at 20A degrees C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured before and after the cooling. Mini Mental State Examination (MMSE) test and nasal inspection were done before and after the cooling. Questionnaires about the subjects' personal experience were completed after the experiment. Brain temperature decrease measured by MRSI was -1.7 +/- A 0.8A degrees C and by phase-mapping -1.8 +/- A 0.9A degrees C (n = 9) at the end of cooling. Spatial distribution of temperature changes was relatively uniform. Rectal temperature decreased by -0.5 +/- A 0.3A degrees C (n = 5). The physiological parameters were stable and no shivering was reported. The volunteers remained alert during cooling and no cognitive dysfunctions were apparent in the MMSE test. Postcooling nasal examination detected increased nasal secretion in nine of the ten volunteers. Volunteers' acceptance of the method was good. Both MR techniques revealed brain temperature reductions after 60 min of intranasal cooling with balloons circulated with saline at 20A degrees C in awake, unsedated volunteers.},
  author       = {Covaciu, L. and Weis, J. and Bengtsson, C and Allers, M. and Lunderquist, Anders and Ahlstrom, H. and Rubertsson, S.},
  issn         = {0342-4642},
  keyword      = {Therapeutic hypothermia,Brain temperature,Magnetic resonance,spectroscopy,Selective brain cooling,Trigeminal reflex},
  language     = {eng},
  number       = {8},
  pages        = {1277--1284},
  publisher    = {Springer},
  series       = {Intensive Care Medicine},
  title        = {Brain temperature in volunteers subjected to intranasal cooling},
  url          = {http://dx.doi.org/10.1007/s00134-011-2264-7},
  volume       = {37},
  year         = {2011},
}