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Fibrocytes and the tissue niche in lung repair

Andersson Sjöland, Annika LU ; Nihlberg, Kristian LU ; Eriksson, Leif LU ; Bjermer, Leif LU and Westergren-Thorsson, Gunilla LU (2011) In Respiratory Research 12.
Abstract
Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological... (More)
Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Respiratory Research
volume
12
publisher
BioMed Central
external identifiers
  • wos:000292596900001
  • scopus:79958055758
ISSN
1465-9921
DOI
10.1186/1465-9921-12-76
language
English
LU publication?
yes
id
ef0d2597-ae67-400f-84d5-bb37f0da8589 (old id 2092850)
date added to LUP
2011-09-02 08:34:48
date last changed
2017-10-22 03:04:06
@article{ef0d2597-ae67-400f-84d5-bb37f0da8589,
  abstract     = {Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases.},
  author       = {Andersson Sjöland, Annika and Nihlberg, Kristian and Eriksson, Leif and Bjermer, Leif and Westergren-Thorsson, Gunilla},
  issn         = {1465-9921},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Respiratory Research},
  title        = {Fibrocytes and the tissue niche in lung repair},
  url          = {http://dx.doi.org/10.1186/1465-9921-12-76},
  volume       = {12},
  year         = {2011},
}