Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics
(1999) In American Journal of Pathology 155(1). p.61-66- Abstract
- Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by metaphase fluorescence in situ hybridization. In all cases, complex rearrangements leading to loss of chromosome 11 material were found. Deletions were present not only in those chromosomes that were shown to be rearranged by G-banding, but in four cases also in the ostensibly normal homologues, resulting in homozygous loss of several loci. Among these, the gene for multiple endocrine neoplasia type I (MEN1) was most frequently deleted. In addition to the MEN1 deletions, heterozygous loss of a second region, approximately 3 Mb distal to MEN1, was... (More)
- Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by metaphase fluorescence in situ hybridization. In all cases, complex rearrangements leading to loss of chromosome 11 material were found. Deletions were present not only in those chromosomes that were shown to be rearranged by G-banding, but in four cases also in the ostensibly normal homologues, resulting in homozygous loss of several loci. Among these, the gene for multiple endocrine neoplasia type I (MEN1) was most frequently deleted. In addition to the MEN1 deletions, heterozygous loss of a second region, approximately 3 Mb distal to MEN1, was found in all five cases, adding to previous evidence for a second tumor suppressor locus in 11q13. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115082
- author
- Gisselsson Nord, David LU ; Höglund, Mattias LU ; Mertens, Fredrik LU ; Dal Cin, Paola and Mandahl, Nils LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Pathology
- volume
- 155
- issue
- 1
- pages
- 61 - 66
- publisher
- American Society for Investigative Pathology
- external identifiers
-
- pmid:10393837
- scopus:0345004941
- ISSN
- 1525-2191
- DOI
- 10.1016/S0002-9440(10)65099-7
- language
- English
- LU publication?
- yes
- id
- 20b9a10a-2e2c-4660-a746-9d032ff6a860 (old id 1115082)
- date added to LUP
- 2016-04-01 11:40:02
- date last changed
- 2024-06-24 05:16:00
@article{20b9a10a-2e2c-4660-a746-9d032ff6a860, abstract = {{Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by metaphase fluorescence in situ hybridization. In all cases, complex rearrangements leading to loss of chromosome 11 material were found. Deletions were present not only in those chromosomes that were shown to be rearranged by G-banding, but in four cases also in the ostensibly normal homologues, resulting in homozygous loss of several loci. Among these, the gene for multiple endocrine neoplasia type I (MEN1) was most frequently deleted. In addition to the MEN1 deletions, heterozygous loss of a second region, approximately 3 Mb distal to MEN1, was found in all five cases, adding to previous evidence for a second tumor suppressor locus in 11q13.}}, author = {{Gisselsson Nord, David and Höglund, Mattias and Mertens, Fredrik and Dal Cin, Paola and Mandahl, Nils}}, issn = {{1525-2191}}, language = {{eng}}, number = {{1}}, pages = {{61--66}}, publisher = {{American Society for Investigative Pathology}}, series = {{American Journal of Pathology}}, title = {{Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics}}, url = {{http://dx.doi.org/10.1016/S0002-9440(10)65099-7}}, doi = {{10.1016/S0002-9440(10)65099-7}}, volume = {{155}}, year = {{1999}}, }