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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Sherborne, Amy L.; Hosking, Fay J.; Prasad, Rashmi B LU ; Kumar, Rajiv; Koehler, Rolf; Vijayakrishnan, Jayaram; Papaemmanuil, Elli; Bartram, Claus R.; Stanulla, Martin and Schrappe, Martin, et al. (2010) In Nature Genetics 42(6). p.4-492
Abstract

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

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type
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publication status
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keywords
Case-Control Studies, Chromosomes, Human, Pair 9, Genes, p16, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Journal Article, Research Support, Non-U.S. Gov't
in
Nature Genetics
volume
42
issue
6
pages
3 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:77952884769
ISSN
1546-1718
DOI
10.1038/ng.585
language
English
LU publication?
no
id
20c09338-9512-40ce-a42f-69179ad044c3
date added to LUP
2017-06-16 09:20:08
date last changed
2018-09-23 04:49:09
@article{20c09338-9512-40ce-a42f-69179ad044c3,
  abstract     = {<p>Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.</p>},
  author       = {Sherborne, Amy L. and Hosking, Fay J. and Prasad, Rashmi B and Kumar, Rajiv and Koehler, Rolf and Vijayakrishnan, Jayaram and Papaemmanuil, Elli and Bartram, Claus R. and Stanulla, Martin and Schrappe, Martin and Gast, Andreas and Dobbins, Sara E. and Ma, Yussanne and Sheridan, Eamonn and Taylor, Malcolm and Kinsey, Sally E. and Lightfoot, Tracey and Roman, Eve and Irving, Julie A E and Allan, James M. and Moorman, Anthony V. and Harrison, Christine J. and Tomlinson, Ian P. and Richards, Sue and Zimmermann, Martin and Szalai, Csaba and Semsei, Agnes F and Erdelyi, Daniel J and Krajinovic, Maja and Sinnett, Daniel and Healy, Jasmine and Gonzalez-Neira, Anna and Kawamata, Norihiko and Ogawa, Seishi and Koeffler, H. Phillip and Hemminki, Kari and Greaves, Mel and Houlston, Richard S},
  issn         = {1546-1718},
  keyword      = {Case-Control Studies,Chromosomes, Human, Pair 9,Genes, p16,Genetic Predisposition to Disease,Genome-Wide Association Study,Humans,Precursor Cell Lymphoblastic Leukemia-Lymphoma,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {6},
  pages        = {4--492},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk},
  url          = {http://dx.doi.org/10.1038/ng.585},
  volume       = {42},
  year         = {2010},
}