Sudden cardiac death in synucleinopathies
Javanshiri, Keivan LU
; Drakenberg, Tove
; Haglund, Mattias
LU
and Englund, Elisabet
LU
(2023)
In Journal of Neuropathology and Experimental Neurology
82(3).
p.242-249
- Abstract
- The purpose of this study was to investigate the cause of death in subjects with α-synucleinopathies (ASs) and the confirmed presence of cardiac α-synuclein (α-syn), compared to non-AS disorders in a neuropathologically confirmed cohort. In total, 78 neuropathologically confirmed AS cases positive for cardiac α-syn were included in the study. Individuals with other neurocognitive diseases, having no α-syn in the brainstem or above, nor in cardiac nerves, served as controls (n = 53). Data regarding the cause of death, cardiac α-syn, pathological cardiac findings, and cardio- and cerebrovascular disease were assembled from autopsy reports and medical records. In the AS group, there was a significantly higher prevalence of sudden cardiac... (More)
- The purpose of this study was to investigate the cause of death in subjects with α-synucleinopathies (ASs) and the confirmed presence of cardiac α-synuclein (α-syn), compared to non-AS disorders in a neuropathologically confirmed cohort. In total, 78 neuropathologically confirmed AS cases positive for cardiac α-syn were included in the study. Individuals with other neurocognitive diseases, having no α-syn in the brainstem or above, nor in cardiac nerves, served as controls (n = 53). Data regarding the cause of death, cardiac α-syn, pathological cardiac findings, and cardio- and cerebrovascular disease were assembled from autopsy reports and medical records. In the AS group, there was a significantly higher prevalence of sudden cardiac death ([SCD]; n = 40, 51.3%) compared to the control group (n = 12, 22.6%, p (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/20c7c705-bf41-455d-b45a-a92cb0ab7be7
- author
- Javanshiri, Keivan
LU
; Drakenberg, Tove
; Haglund, Mattias
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuropathology and Experimental Neurology
- volume
- 82
- issue
- 3
- pages
- 242 - 249
- publisher
- American Association of Neuropathologists
- external identifiers
-
- pmid:36668680
- scopus:85148479533
- ISSN
- 1554-6578
- DOI
- 10.1093/jnen/nlad001
- language
- English
- LU publication?
- yes
- id
- 20c7c705-bf41-455d-b45a-a92cb0ab7be7
- date added to LUP
- 2023-01-24 11:55:34
- date last changed
- 2024-05-16 08:54:29
@article{20c7c705-bf41-455d-b45a-a92cb0ab7be7,
abstract = {{The purpose of this study was to investigate the cause of death in subjects with α-synucleinopathies (ASs) and the confirmed presence of cardiac α-synuclein (α-syn), compared to non-AS disorders in a neuropathologically confirmed cohort. In total, 78 neuropathologically confirmed AS cases positive for cardiac α-syn were included in the study. Individuals with other neurocognitive diseases, having no α-syn in the brainstem or above, nor in cardiac nerves, served as controls (n = 53). Data regarding the cause of death, cardiac α-syn, pathological cardiac findings, and cardio- and cerebrovascular disease were assembled from autopsy reports and medical records. In the AS group, there was a significantly higher prevalence of sudden cardiac death ([SCD]; n = 40, 51.3%) compared to the control group (n = 12, 22.6%, p}},
author = {{Javanshiri, Keivan and Drakenberg, Tove and Haglund, Mattias and Englund, Elisabet}},
issn = {{1554-6578}},
language = {{eng}},
number = {{3}},
pages = {{242--249}},
publisher = {{American Association of Neuropathologists}},
series = {{Journal of Neuropathology and Experimental Neurology}},
title = {{Sudden cardiac death in synucleinopathies}},
url = {{http://dx.doi.org/10.1093/jnen/nlad001}},
doi = {{10.1093/jnen/nlad001}},
volume = {{82}},
year = {{2023}},
}