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Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when compared with standard investigations

Schmiegelow, Kjeld ; Simes, Martti A ; Agertoft, Lone ; Berglund, Gunilla ; Storm-Mathisen, Ingebjörn ; Andreassen, Michael ; Salmi, Toivo T ; Nygard, Randi ; Wiebe, Thomas LU and Kreuger, Anders , et al. (1989) In Medical and Pediatric Oncology 17(2). p.126-130
Abstract
Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy... (More)
Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MIBG scintigraphy, sensitivity, specificity, predictive value
in
Medical and Pediatric Oncology
volume
17
issue
2
pages
126 - 130
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:2649775
  • scopus:0024526167
ISSN
1096-911X
DOI
10.1002/mpo.2950170210
language
English
LU publication?
yes
id
20cb017b-294b-4052-8745-02ce0a9bf8e3 (old id 1104695)
date added to LUP
2016-04-01 11:41:34
date last changed
2021-09-26 03:10:17
@article{20cb017b-294b-4052-8745-02ce0a9bf8e3,
  abstract     = {{Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy.}},
  author       = {{Schmiegelow, Kjeld and Simes, Martti A and Agertoft, Lone and Berglund, Gunilla and Storm-Mathisen, Ingebjörn and Andreassen, Michael and Salmi, Toivo T and Nygard, Randi and Wiebe, Thomas and Kreuger, Anders and Hayder, Salah}},
  issn         = {{1096-911X}},
  keywords     = {{MIBG scintigraphy; sensitivity; specificity; predictive value}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{126--130}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Medical and Pediatric Oncology}},
  title        = {{Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when compared with standard investigations}},
  url          = {{http://dx.doi.org/10.1002/mpo.2950170210}},
  doi          = {{10.1002/mpo.2950170210}},
  volume       = {{17}},
  year         = {{1989}},
}