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Use of antiemetic drugs during pregnancy in Sweden

Asker, C; Norstedt Wikner, B and Källén, Bengt LU (2005) In European Journal of Clinical Pharmacology 61(12). p.899-906
Abstract
Background: More than one-half of all pregnant women suffer from nausea and vomiting during pregnancy (NVP), primarily during the first trimester. Methods: Prospectively ascertained information on drug use during pregnancy was obtained from the Swedish Medical Birth Register during the period July 1, 1995 to 2002. Antiemetics (antiemetic antihistamines, dopamine modulators, and ondansetron) primarily used for NVP were studied, and women reporting the use of these drugs were compared with all women who gave birth during the study period. Results: Use of these antiemetics was reported in 4.5% of the pregnant women - 86% of whom reported their use before the first antenatal visit (usually weeks 10-12). Meclozine, followed by other... (More)
Background: More than one-half of all pregnant women suffer from nausea and vomiting during pregnancy (NVP), primarily during the first trimester. Methods: Prospectively ascertained information on drug use during pregnancy was obtained from the Swedish Medical Birth Register during the period July 1, 1995 to 2002. Antiemetics (antiemetic antihistamines, dopamine modulators, and ondansetron) primarily used for NVP were studied, and women reporting the use of these drugs were compared with all women who gave birth during the study period. Results: Use of these antiemetics was reported in 4.5% of the pregnant women - 86% of whom reported their use before the first antenatal visit (usually weeks 10-12). Meclozine, followed by other antihistamines, accounted for 68% of the drugs reported. Young maternal age, multiparity, non-smoking, and a period of unwanted childlessness increased the probability of using any of the antiemetics during pregnancy. Women with a low education used these drugs more often than women with a relatively higher education. Neonates born to women who used any of the antiemetics had a reduced risk for low birthweight, prematurity, being small-for-gestational age, and having a malformation. No specific differences were observed with respect to the outcome following a comparison of different antiemetic drugs. Conclusions: Women using antiemetics as a rule have a better delivery outcome than other women, probably due to an effect of a well-functioning placenta, which is associated with NVP. There were no signs of any significant teratogenicity of the drugs studied, but for some drugs the number of exposures was low. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
malformations, congenital, low birth weight, preterm birth, antiemetics, pregnancy, epidemiology
in
European Journal of Clinical Pharmacology
volume
61
issue
12
pages
899 - 906
publisher
Springer
external identifiers
  • pmid:16328314
  • wos:000234021200006
  • scopus:29144525918
ISSN
1432-1041
DOI
10.1007/s00228-005-0055-1
language
English
LU publication?
yes
id
e98ac606-fd7e-49fd-852c-036f79262721 (old id 211022)
date added to LUP
2007-09-17 18:48:24
date last changed
2017-05-07 04:17:20
@article{e98ac606-fd7e-49fd-852c-036f79262721,
  abstract     = {Background: More than one-half of all pregnant women suffer from nausea and vomiting during pregnancy (NVP), primarily during the first trimester. Methods: Prospectively ascertained information on drug use during pregnancy was obtained from the Swedish Medical Birth Register during the period July 1, 1995 to 2002. Antiemetics (antiemetic antihistamines, dopamine modulators, and ondansetron) primarily used for NVP were studied, and women reporting the use of these drugs were compared with all women who gave birth during the study period. Results: Use of these antiemetics was reported in 4.5% of the pregnant women - 86% of whom reported their use before the first antenatal visit (usually weeks 10-12). Meclozine, followed by other antihistamines, accounted for 68% of the drugs reported. Young maternal age, multiparity, non-smoking, and a period of unwanted childlessness increased the probability of using any of the antiemetics during pregnancy. Women with a low education used these drugs more often than women with a relatively higher education. Neonates born to women who used any of the antiemetics had a reduced risk for low birthweight, prematurity, being small-for-gestational age, and having a malformation. No specific differences were observed with respect to the outcome following a comparison of different antiemetic drugs. Conclusions: Women using antiemetics as a rule have a better delivery outcome than other women, probably due to an effect of a well-functioning placenta, which is associated with NVP. There were no signs of any significant teratogenicity of the drugs studied, but for some drugs the number of exposures was low.},
  author       = {Asker, C and Norstedt Wikner, B and Källén, Bengt},
  issn         = {1432-1041},
  keyword      = {malformations,congenital,low birth weight,preterm birth,antiemetics,pregnancy,epidemiology},
  language     = {eng},
  number       = {12},
  pages        = {899--906},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Use of antiemetic drugs during pregnancy in Sweden},
  url          = {http://dx.doi.org/10.1007/s00228-005-0055-1},
  volume       = {61},
  year         = {2005},
}