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Influence of dexamethasone and alpha-ketoglutarate administration to pregnant sows on the level of some hormones in the blood plasma of newborn un-suckled piglets

Sliwa, E; Tatara, MR; Pierzynowski, Stefan LU and Studzinski, T (2005) In Medycyna Weterynaryjna 61(12). p.1405-1407
Abstract
The aim of the study was to establish the influence of dexamethasone and alpha-ketoglutarate administration to pregnant sows on the prenatal programming of the growth hormone level, cortisol, insulin and IGF-I in the blood serum of newborn piglets assessed just after their birth and prior to suckling. The foetal development is dependent on and determined by hormones such as glucocorticoids as well as nutrient supply through the sow, especially from the digestive tract. All these factors determine pre- and neonatal growth. The experiment was conducted over the final 24 days of pregnancy in sows treated i.m. with dexamethasone at a dose of 3 mg per sow every second day or alpha-ketoglutarate administered orally daily at a dose of 0.4 g/kg... (More)
The aim of the study was to establish the influence of dexamethasone and alpha-ketoglutarate administration to pregnant sows on the prenatal programming of the growth hormone level, cortisol, insulin and IGF-I in the blood serum of newborn piglets assessed just after their birth and prior to suckling. The foetal development is dependent on and determined by hormones such as glucocorticoids as well as nutrient supply through the sow, especially from the digestive tract. All these factors determine pre- and neonatal growth. The experiment was conducted over the final 24 days of pregnancy in sows treated i.m. with dexamethasone at a dose of 3 mg per sow every second day or alpha-ketoglutarate administered orally daily at a dose of 0.4 g/kg b.w. The blood samples were collected from the subclavian vein of un-suckled piglets immediately following their birth and were centrifuged straight away and the serum stored at -25 degrees C until further analysis. Hormone concentrations were determined using ELISA kit. The obtained results indicate that maternal administration of dexamethasone increased the level of cortisol while alpha-ketoglutarate increased the levels of cortisol and IGF I whereas simultaneous administration of dexamethasone and AKG significantly increased the growth hormone. These results of separate or simultaneous maternal administration of dexamethasone and alpha-ketogluta rate during the last 24 days of pregnancy indicated the activation of different mechanisms and different prenatal effects on the levels of cortisol, growth hormone and IGF I in serum assessed immediately following the birth of the piglets. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-ketoglutarate, piglets, dexamethasone, growth hormone
in
Medycyna Weterynaryjna
volume
61
issue
12
pages
1405 - 1407
publisher
POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE
external identifiers
  • wos:000233626700022
  • scopus:29344467211
ISSN
0025-8628
language
Polish
LU publication?
yes
id
24ff5cc0-07b2-4f04-af7e-cc9f8048a67e (old id 211501)
date added to LUP
2007-08-15 15:43:27
date last changed
2017-01-01 07:10:30
@article{24ff5cc0-07b2-4f04-af7e-cc9f8048a67e,
  abstract     = {The aim of the study was to establish the influence of dexamethasone and alpha-ketoglutarate administration to pregnant sows on the prenatal programming of the growth hormone level, cortisol, insulin and IGF-I in the blood serum of newborn piglets assessed just after their birth and prior to suckling. The foetal development is dependent on and determined by hormones such as glucocorticoids as well as nutrient supply through the sow, especially from the digestive tract. All these factors determine pre- and neonatal growth. The experiment was conducted over the final 24 days of pregnancy in sows treated i.m. with dexamethasone at a dose of 3 mg per sow every second day or alpha-ketoglutarate administered orally daily at a dose of 0.4 g/kg b.w. The blood samples were collected from the subclavian vein of un-suckled piglets immediately following their birth and were centrifuged straight away and the serum stored at -25 degrees C until further analysis. Hormone concentrations were determined using ELISA kit. The obtained results indicate that maternal administration of dexamethasone increased the level of cortisol while alpha-ketoglutarate increased the levels of cortisol and IGF I whereas simultaneous administration of dexamethasone and AKG significantly increased the growth hormone. These results of separate or simultaneous maternal administration of dexamethasone and alpha-ketogluta rate during the last 24 days of pregnancy indicated the activation of different mechanisms and different prenatal effects on the levels of cortisol, growth hormone and IGF I in serum assessed immediately following the birth of the piglets.},
  author       = {Sliwa, E and Tatara, MR and Pierzynowski, Stefan and Studzinski, T},
  issn         = {0025-8628},
  keyword      = {alpha-ketoglutarate,piglets,dexamethasone,growth hormone},
  language     = {pol},
  number       = {12},
  pages        = {1405--1407},
  publisher    = {POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE},
  series       = {Medycyna Weterynaryjna},
  title        = {Influence of dexamethasone and alpha-ketoglutarate administration to pregnant sows on the level of some hormones in the blood plasma of newborn un-suckled piglets},
  volume       = {61},
  year         = {2005},
}