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Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption

Michael, H; Härkönen, Pirkko LU ; Vaananen, H K and Hentunen, T A (2005) In Journal of Bone and Mineral Research 20(12). p.2224-2232
Abstract
Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
estrogen receptor, androgen receptor, estrogen, testosterone, human CD14(+) monocytes, bone resorption, osteoclast formation
in
Journal of Bone and Mineral Research
volume
20
issue
12
pages
2224 - 2232
publisher
AMBMR
external identifiers
  • pmid:16294275
  • wos:000233517700016
  • scopus:27744431505
ISSN
1523-4681
DOI
10.1359/JBMR.050803
language
English
LU publication?
yes
id
00603203-1c97-4f51-994b-d408a4cb4468 (old id 212151)
date added to LUP
2007-08-10 15:48:55
date last changed
2017-11-19 03:26:15
@article{00603203-1c97-4f51-994b-d408a4cb4468,
  abstract     = {Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.},
  author       = {Michael, H and Härkönen, Pirkko and Vaananen, H K and Hentunen, T A},
  issn         = {1523-4681},
  keyword      = {estrogen receptor,androgen receptor,estrogen,testosterone,human CD14(+) monocytes,bone resorption,osteoclast formation},
  language     = {eng},
  number       = {12},
  pages        = {2224--2232},
  publisher    = {AMBMR},
  series       = {Journal of Bone and Mineral Research},
  title        = {Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption},
  url          = {http://dx.doi.org/10.1359/JBMR.050803},
  volume       = {20},
  year         = {2005},
}