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Conjugated linoleic acid increased C-reactive protein in human subjects

Smedman, A; Basu, S; Jovinge, Stefan LU ; Nordin Fredrikson, Gunilla LU and Vessby, B (2005) In British Journal of Nutrition 94(5). p.791-795
Abstract
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the... (More)
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumour necrosis, conjugated linoleic acid, C-reactive protein, inflammation, factor-alpha
in
British Journal of Nutrition
volume
94
issue
5
pages
791 - 795
publisher
Cambridge University Press
external identifiers
  • wos:000233096600024
  • pmid:16277783
  • scopus:27144541775
ISSN
1475-2662
DOI
10.1079/BJN20041419
language
English
LU publication?
yes
id
a5dc0684-b49a-4d9e-8b59-38be070a3b2c (old id 214010)
date added to LUP
2007-08-08 09:10:41
date last changed
2017-07-02 03:32:02
@article{a5dc0684-b49a-4d9e-8b59-38be070a3b2c,
  abstract     = {We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.},
  author       = {Smedman, A and Basu, S and Jovinge, Stefan and Nordin Fredrikson, Gunilla and Vessby, B},
  issn         = {1475-2662},
  keyword      = {tumour necrosis,conjugated linoleic acid,C-reactive protein,inflammation,factor-alpha},
  language     = {eng},
  number       = {5},
  pages        = {791--795},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Conjugated linoleic acid increased C-reactive protein in human subjects},
  url          = {http://dx.doi.org/10.1079/BJN20041419},
  volume       = {94},
  year         = {2005},
}