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The role of p-c-Jun in survival and outgrowth of developing sensory neurons

Lindwall, Charlotta LU and Kanje, Martin LU (2005) In NeuroReport 16(15). p.1655-1659
Abstract
c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun... (More)
c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nerve growth, dorsal root ganglia, development, c-Jun, (D)-JNKII, rat, factor
in
NeuroReport
volume
16
issue
15
pages
1655 - 1659
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:16189472
  • wos:000233073900009
  • scopus:29144475318
ISSN
1473-558X
language
English
LU publication?
yes
id
81b12a3b-a72b-42a3-85e9-610d932a4dc9 (old id 214182)
date added to LUP
2007-09-28 15:45:07
date last changed
2017-01-01 04:34:35
@article{81b12a3b-a72b-42a3-85e9-610d932a4dc9,
  abstract     = {c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.},
  author       = {Lindwall, Charlotta and Kanje, Martin},
  issn         = {1473-558X},
  keyword      = {nerve growth,dorsal root ganglia,development,c-Jun,(D)-JNKII,rat,factor},
  language     = {eng},
  number       = {15},
  pages        = {1655--1659},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {The role of p-c-Jun in survival and outgrowth of developing sensory neurons},
  volume       = {16},
  year         = {2005},
}