Advanced

Intraoperative fall in plasma levels of intact parathyroid hormone after removal of one enlarged parathyroid gland in hyperparathyroid patients

Bergenfelz, A LU ; Nordén, N E LU and Ahrén, B LU (1991) In Acta Chirurgica Scandinavica 157(2). p.12-109
Abstract

Plasma levels of intact parathyroid hormone (PTH) were measured intraoperatively before and after removal of one enlarged gland in 20 hyperparathyroid patients. In 13 patients with a single parathyroid adenoma, plasma levels of intact PTH-(1-84) had declined at 15 min after removal of the adenoma by 86.5 +/- 4.4% of baseline in the antecubital vein and by 85.6 +/- 4.2% in the ipsilateral internal jugular vein. In seven patients with parathyroid hyperplasia, the corresponding figures for decline at 15 min after removal of one enlarged parathyroid gland were only 26.6 +/- 6.4% and 7.8 +/- 29.4%. The fall in PTH levels was significantly less in hyperplasia than in adenoma (p less than 0.001). Thus 15 min after removal of one enlarged... (More)

Plasma levels of intact parathyroid hormone (PTH) were measured intraoperatively before and after removal of one enlarged gland in 20 hyperparathyroid patients. In 13 patients with a single parathyroid adenoma, plasma levels of intact PTH-(1-84) had declined at 15 min after removal of the adenoma by 86.5 +/- 4.4% of baseline in the antecubital vein and by 85.6 +/- 4.2% in the ipsilateral internal jugular vein. In seven patients with parathyroid hyperplasia, the corresponding figures for decline at 15 min after removal of one enlarged parathyroid gland were only 26.6 +/- 6.4% and 7.8 +/- 29.4%. The fall in PTH levels was significantly less in hyperplasia than in adenoma (p less than 0.001). Thus 15 min after removal of one enlarged parathyroid gland, the decline in plasma level of intact PTH may distinguish between single adenoma and multiglandular disease as the cause of hyperparathyroidism.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenoma, Female, Humans, Hyperparathyroidism, Hyperplasia, Immunoradiometric Assay, Intraoperative Period, Male, Middle Aged, Parathyroid Glands, Parathyroid Hormone, Parathyroid Neoplasms, Reoperation, Journal Article
in
Acta Chirurgica Scandinavica
volume
157
issue
2
pages
4 pages
publisher
Almqvist & Wiksell
external identifiers
  • scopus:0025735285
ISSN
0001-5482
language
English
LU publication?
yes
id
21457ada-b104-48e4-b75a-8100f9c7017e
date added to LUP
2017-05-10 13:48:39
date last changed
2017-05-23 08:46:15
@article{21457ada-b104-48e4-b75a-8100f9c7017e,
  abstract     = {<p>Plasma levels of intact parathyroid hormone (PTH) were measured intraoperatively before and after removal of one enlarged gland in 20 hyperparathyroid patients. In 13 patients with a single parathyroid adenoma, plasma levels of intact PTH-(1-84) had declined at 15 min after removal of the adenoma by 86.5 +/- 4.4% of baseline in the antecubital vein and by 85.6 +/- 4.2% in the ipsilateral internal jugular vein. In seven patients with parathyroid hyperplasia, the corresponding figures for decline at 15 min after removal of one enlarged parathyroid gland were only 26.6 +/- 6.4% and 7.8 +/- 29.4%. The fall in PTH levels was significantly less in hyperplasia than in adenoma (p less than 0.001). Thus 15 min after removal of one enlarged parathyroid gland, the decline in plasma level of intact PTH may distinguish between single adenoma and multiglandular disease as the cause of hyperparathyroidism.</p>},
  author       = {Bergenfelz, A and Nordén, N E and Ahrén, B},
  issn         = {0001-5482},
  keyword      = {Adenoma,Female,Humans,Hyperparathyroidism,Hyperplasia,Immunoradiometric Assay,Intraoperative Period,Male,Middle Aged,Parathyroid Glands,Parathyroid Hormone,Parathyroid Neoplasms,Reoperation,Journal Article},
  language     = {eng},
  number       = {2},
  pages        = {12--109},
  publisher    = {Almqvist & Wiksell},
  series       = {Acta Chirurgica Scandinavica},
  title        = {Intraoperative fall in plasma levels of intact parathyroid hormone after removal of one enlarged parathyroid gland in hyperparathyroid patients},
  volume       = {157},
  year         = {1991},
}