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What is the Role of Chemotherapy in Endometrial Cancer?

Högberg, Thomas LU (2011) In Current Oncology Reports 13. p.433-441
Abstract
Adjuvant pelvic radiotherapy has the potential to eradicate micrometastases within the irradiated field but has not resulted in survival improvements in randomized studies. This illustrates the need for systemic therapy. Chemotherapy, mainly with anthracyclines, platinum compounds, and taxanes, renders high response rates although this unfortunately translates in only modest improvements in progression-free and overall survival. Better systemic treatments need to be developed. Investigations of the molecular mechanisms of endometrial cancer have identified possible targets for therapy. In advanced endometrial cancer one study shows that chemotherapy is better than whole abdominal radiotherapy, while in the adjuvant situation the... (More)
Adjuvant pelvic radiotherapy has the potential to eradicate micrometastases within the irradiated field but has not resulted in survival improvements in randomized studies. This illustrates the need for systemic therapy. Chemotherapy, mainly with anthracyclines, platinum compounds, and taxanes, renders high response rates although this unfortunately translates in only modest improvements in progression-free and overall survival. Better systemic treatments need to be developed. Investigations of the molecular mechanisms of endometrial cancer have identified possible targets for therapy. In advanced endometrial cancer one study shows that chemotherapy is better than whole abdominal radiotherapy, while in the adjuvant situation the combination of chemotherapy and radiotherapy appears promising. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Oncology Reports
volume
13
pages
433 - 441
publisher
Current Science, Inc.
external identifiers
  • wos:000296881500003
  • pmid:21874283
  • scopus:81155133815
ISSN
1523-3790
DOI
10.1007/s11912-011-0192-x
language
English
LU publication?
yes
id
fb209f7e-b3de-41e0-9c95-d2b68923f635 (old id 2150588)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21874283?dopt=Abstract
date added to LUP
2011-09-04 22:25:27
date last changed
2017-07-23 04:54:45
@article{fb209f7e-b3de-41e0-9c95-d2b68923f635,
  abstract     = {Adjuvant pelvic radiotherapy has the potential to eradicate micrometastases within the irradiated field but has not resulted in survival improvements in randomized studies. This illustrates the need for systemic therapy. Chemotherapy, mainly with anthracyclines, platinum compounds, and taxanes, renders high response rates although this unfortunately translates in only modest improvements in progression-free and overall survival. Better systemic treatments need to be developed. Investigations of the molecular mechanisms of endometrial cancer have identified possible targets for therapy. In advanced endometrial cancer one study shows that chemotherapy is better than whole abdominal radiotherapy, while in the adjuvant situation the combination of chemotherapy and radiotherapy appears promising.},
  author       = {Högberg, Thomas},
  issn         = {1523-3790},
  language     = {eng},
  pages        = {433--441},
  publisher    = {Current Science, Inc.},
  series       = {Current Oncology Reports},
  title        = {What is the Role of Chemotherapy in Endometrial Cancer?},
  url          = {http://dx.doi.org/10.1007/s11912-011-0192-x},
  volume       = {13},
  year         = {2011},
}