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Is smoking a risk factor for collagenous colitis?

Vigren, Lina LU ; Sjöberg, Klas LU ; Benoni, Cecilia LU ; Tysk, Curt; Bohr, Johan; Kilander, Anders; Larsson, Lasse; Ström, Magnus and Hjortswang, Henrik (2011) In Scandinavian Journal of Gastroenterology 46. p.1334-1339
Abstract
Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe whether smoking had any impact on the course of the disease. Materials and methods. 116 patients (92 women) with median age of 62 years (interquartile range 55-73) answered questionnaires covering demographic data, smoking habits and disease activity. As control group we used data from the general population in Sweden retrieved from Statistics... (More)
Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe whether smoking had any impact on the course of the disease. Materials and methods. 116 patients (92 women) with median age of 62 years (interquartile range 55-73) answered questionnaires covering demographic data, smoking habits and disease activity. As control group we used data from the general population in Sweden retrieved from Statistics Sweden, the central bureau for national socioeconomic information. Results. Of the 116 CC patients, 37% were smokers compared with 17% of controls (p < 0.001, odds ratio (OR) 2.95). In the age group 16-44 years, 75% of CC patients were smokers compared with 15% of controls (p < 0.001, OR 16.54). All CC smoker patients started smoking before the onset of disease. Furthermore, smokers developed the disease earlier than non-smokers - at 42 years of age (median) compared with 56 years in non-smokers (p < 0.003). Although the proportion with active disease did not differ between smokers and non-smokers, there was a trend indicating that more smokers received active treatment (42% vs. 17%, p = 0.078). Conclusions. Smoking is a risk factor for CC. Smokers develop their disease more than 10 years earlier than non-smokers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
46
pages
1334 - 1339
publisher
Taylor & Francis
external identifiers
  • wos:000295892100008
  • pmid:21854096
  • scopus:80054078738
ISSN
1502-7708
DOI
10.3109/00365521.2011.610005
language
English
LU publication?
yes
id
4be32426-8bdd-4cff-ab52-a3f2c4a79224 (old id 2150828)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21854096?dopt=Abstract
date added to LUP
2011-09-04 13:48:03
date last changed
2017-06-11 04:01:14
@article{4be32426-8bdd-4cff-ab52-a3f2c4a79224,
  abstract     = {Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe whether smoking had any impact on the course of the disease. Materials and methods. 116 patients (92 women) with median age of 62 years (interquartile range 55-73) answered questionnaires covering demographic data, smoking habits and disease activity. As control group we used data from the general population in Sweden retrieved from Statistics Sweden, the central bureau for national socioeconomic information. Results. Of the 116 CC patients, 37% were smokers compared with 17% of controls (p &lt; 0.001, odds ratio (OR) 2.95). In the age group 16-44 years, 75% of CC patients were smokers compared with 15% of controls (p &lt; 0.001, OR 16.54). All CC smoker patients started smoking before the onset of disease. Furthermore, smokers developed the disease earlier than non-smokers - at 42 years of age (median) compared with 56 years in non-smokers (p &lt; 0.003). Although the proportion with active disease did not differ between smokers and non-smokers, there was a trend indicating that more smokers received active treatment (42% vs. 17%, p = 0.078). Conclusions. Smoking is a risk factor for CC. Smokers develop their disease more than 10 years earlier than non-smokers.},
  author       = {Vigren, Lina and Sjöberg, Klas and Benoni, Cecilia and Tysk, Curt and Bohr, Johan and Kilander, Anders and Larsson, Lasse and Ström, Magnus and Hjortswang, Henrik},
  issn         = {1502-7708},
  language     = {eng},
  pages        = {1334--1339},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Is smoking a risk factor for collagenous colitis?},
  url          = {http://dx.doi.org/10.3109/00365521.2011.610005},
  volume       = {46},
  year         = {2011},
}