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In vivo imaging of astrocytosis in Alzheimer's disease: an (11)C-L: -deuteriodeprenyl and PIB PET study.

Santillo, Alexander LU ; Gambini, Juan Pablo; Lannfelt, Lars; Långström, Bengt; Luohija, Ulla-Maja; Kilander, Lena and Engler, Henry (2011) In European Journal of Nuclear Medicine and Molecular Imaging 38(12). p.2202-2208
Abstract
PURPOSE: Astrocytosis is an important feature of the neuropathology of Alzheimer's disease (AD), yet there is currently no way of detecting this phenomenon in vivo. METHODS: In this study we examine the retention of the positron emission tomography (PET) tracer (11)C-L: -deuteriodeprenyl (DED), thought to bind activated astrocytes, in 9 patients with moderate to severe AD compared with 11 healthy controls. As a measure of amyloid load, (11)C-labelled Pittsburgh Compound B (PIB) retention was determined. RESULTS: Results show a significantly higher (11)C-L: -DED retention in the frontal (35.1% increase, p = 0.001), parietal (35.2%, p = 0.001), temporal (30.9%, p = 0.0001) and medial temporal lobes (22.3%, p = 0.001) in AD compared to... (More)
PURPOSE: Astrocytosis is an important feature of the neuropathology of Alzheimer's disease (AD), yet there is currently no way of detecting this phenomenon in vivo. METHODS: In this study we examine the retention of the positron emission tomography (PET) tracer (11)C-L: -deuteriodeprenyl (DED), thought to bind activated astrocytes, in 9 patients with moderate to severe AD compared with 11 healthy controls. As a measure of amyloid load, (11)C-labelled Pittsburgh Compound B (PIB) retention was determined. RESULTS: Results show a significantly higher (11)C-L: -DED retention in the frontal (35.1% increase, p = 0.001), parietal (35.2%, p = 0.001), temporal (30.9%, p = 0.0001) and medial temporal lobes (22.3%, p = 0.001) in AD compared to healthy controls after blood flow correction. DED retention in the sensorimotor and occipital cortices, and in white matter and subcortical structures, did not differ between groups. There was a moderate but statistically significant (r = 0.492, p = 0.01) correlation between DED and PIB retention values. CONCLUSION: Our conclusion is that DED may serve as an in vivo marker for astrocytosis in AD, providing a window into intermediate processes between amyloidosis and neuronal loss and a means of monitoring immunotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pittsburgh Compound B, C-11-L-deuteriodeprenyl, Astrocytosis, Alzheimer's disease, Positron emission tomography
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
38
issue
12
pages
2202 - 2208
publisher
Springer
external identifiers
  • wos:000297732700012
  • pmid:21853308
  • scopus:84856235427
ISSN
1619-7070
DOI
10.1007/s00259-011-1895-9
language
English
LU publication?
yes
id
1a6fbdda-c426-4c31-a6ff-d3b46dcf02a2 (old id 2150844)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21853308?dopt=Abstract
date added to LUP
2011-09-04 13:41:05
date last changed
2017-11-05 03:01:41
@article{1a6fbdda-c426-4c31-a6ff-d3b46dcf02a2,
  abstract     = {PURPOSE: Astrocytosis is an important feature of the neuropathology of Alzheimer's disease (AD), yet there is currently no way of detecting this phenomenon in vivo. METHODS: In this study we examine the retention of the positron emission tomography (PET) tracer (11)C-L: -deuteriodeprenyl (DED), thought to bind activated astrocytes, in 9 patients with moderate to severe AD compared with 11 healthy controls. As a measure of amyloid load, (11)C-labelled Pittsburgh Compound B (PIB) retention was determined. RESULTS: Results show a significantly higher (11)C-L: -DED retention in the frontal (35.1% increase, p = 0.001), parietal (35.2%, p = 0.001), temporal (30.9%, p = 0.0001) and medial temporal lobes (22.3%, p = 0.001) in AD compared to healthy controls after blood flow correction. DED retention in the sensorimotor and occipital cortices, and in white matter and subcortical structures, did not differ between groups. There was a moderate but statistically significant (r = 0.492, p = 0.01) correlation between DED and PIB retention values. CONCLUSION: Our conclusion is that DED may serve as an in vivo marker for astrocytosis in AD, providing a window into intermediate processes between amyloidosis and neuronal loss and a means of monitoring immunotherapy.},
  author       = {Santillo, Alexander and Gambini, Juan Pablo and Lannfelt, Lars and Långström, Bengt and Luohija, Ulla-Maja and Kilander, Lena and Engler, Henry},
  issn         = {1619-7070},
  keyword      = {Pittsburgh Compound B,C-11-L-deuteriodeprenyl,Astrocytosis,Alzheimer's disease,Positron emission tomography},
  language     = {eng},
  number       = {12},
  pages        = {2202--2208},
  publisher    = {Springer},
  series       = {European Journal of Nuclear Medicine and Molecular Imaging},
  title        = {In vivo imaging of astrocytosis in Alzheimer's disease: an (11)C-L: -deuteriodeprenyl and PIB PET study.},
  url          = {http://dx.doi.org/10.1007/s00259-011-1895-9},
  volume       = {38},
  year         = {2011},
}