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Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.

Almgren, Peter LU ; Lehtovirta, M; Isomaa, B; Sarelin, L; Taskinen, M R; Lyssenko, Valeriya LU ; Tuomi, Tiinamaija and Groop, Leif LU (2011) In Diabetologia 54. p.2811-2819
Abstract
AIMS/HYPOTHESIS:

To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.



METHODS:

Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.



RESULTS:

The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75... (More)
AIMS/HYPOTHESIS:

To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.



METHODS:

Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.



RESULTS:

The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75 years dropped the h (2) estimates to 0.31. Among quantitative traits, the highest h (2) estimates in all individuals and in non-diabetic individuals were seen for lean body mass (h (2) = 0.53-0.65), HDL-cholesterol (0.52-0.61) and suppression of NEFA during OGTT (0.63-0.76) followed by measures of insulin secretion (insulinogenic index [IG(30)] = 0.41-0.50) and insulin action (insulin sensitivity index [ISI] = 0.37-0.40). In contrast, physical activity showed rather low heritability (0.16-0.18), whereas smoking showed strong heritability (0.57-0.59). Family means of these traits differed two- to fivefold between families belonging to the lowest and highest quartile of the trait (p < 0.00001).



CONCLUSIONS/INTERPRETATION:

To detect stronger genetic effects in type 2 diabetes, it seems reasonable to restrict inclusion of patients to those with age at onset 35-60 years. Sequencing of families with extreme quantitative traits could be an important next step in the dissection of the genetics of type 2 diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
54
pages
2811 - 2819
publisher
Springer Verlag
external identifiers
  • wos:000295679800010
  • pmid:21826484
  • scopus:80054707972
ISSN
1432-0428
DOI
10.1007/s00125-011-2267-5
language
English
LU publication?
yes
id
6f223dd4-6ef0-443e-bf2f-a987ccfad6b1 (old id 2151278)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21826484?dopt=Abstract
date added to LUP
2011-09-04 21:37:00
date last changed
2017-11-19 04:18:03
@article{6f223dd4-6ef0-443e-bf2f-a987ccfad6b1,
  abstract     = {AIMS/HYPOTHESIS:<br/><br>
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.<br/><br>
<br/><br>
METHODS:<br/><br>
Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.<br/><br>
<br/><br>
RESULTS:<br/><br>
The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75 years dropped the h (2) estimates to 0.31. Among quantitative traits, the highest h (2) estimates in all individuals and in non-diabetic individuals were seen for lean body mass (h (2) = 0.53-0.65), HDL-cholesterol (0.52-0.61) and suppression of NEFA during OGTT (0.63-0.76) followed by measures of insulin secretion (insulinogenic index [IG(30)] = 0.41-0.50) and insulin action (insulin sensitivity index [ISI] = 0.37-0.40). In contrast, physical activity showed rather low heritability (0.16-0.18), whereas smoking showed strong heritability (0.57-0.59). Family means of these traits differed two- to fivefold between families belonging to the lowest and highest quartile of the trait (p &lt; 0.00001).<br/><br>
<br/><br>
CONCLUSIONS/INTERPRETATION:<br/><br>
To detect stronger genetic effects in type 2 diabetes, it seems reasonable to restrict inclusion of patients to those with age at onset 35-60 years. Sequencing of families with extreme quantitative traits could be an important next step in the dissection of the genetics of type 2 diabetes.},
  author       = {Almgren, Peter and Lehtovirta, M and Isomaa, B and Sarelin, L and Taskinen, M R and Lyssenko, Valeriya and Tuomi, Tiinamaija and Groop, Leif},
  issn         = {1432-0428},
  language     = {eng},
  pages        = {2811--2819},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.},
  url          = {http://dx.doi.org/10.1007/s00125-011-2267-5},
  volume       = {54},
  year         = {2011},
}