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Abnormal peripheral chemokine profile in Huntington's disease.

Wild, Edward; Magnusson-Lind, Anna LU ; Lahiri, Nayana; Krus, Ulrika LU ; Orth, Michael J; Tabrizi, Sarah J and Björkqvist, Maria LU (2011) In PLoS Currents 3.
Abstract
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease... (More)
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD. (Less)
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organization
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type
Contribution to journal
publication status
published
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in
PLoS Currents
volume
3
publisher
Public Library of Science
external identifiers
  • pmid:21826115
  • scopus:84855975733
ISSN
2157-3999
DOI
10.1371/currents.RRN1231
language
English
LU publication?
yes
id
7c45b648-bb75-40bb-a1de-8aa59d14e5c0 (old id 2151301)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21826115?dopt=Abstract
date added to LUP
2011-09-04 16:00:52
date last changed
2017-06-25 04:40:16
@article{7c45b648-bb75-40bb-a1de-8aa59d14e5c0,
  abstract     = {Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD.},
  articleno    = {RRN1231},
  author       = {Wild, Edward and Magnusson-Lind, Anna and Lahiri, Nayana and Krus, Ulrika and Orth, Michael J and Tabrizi, Sarah J and Björkqvist, Maria},
  issn         = {2157-3999},
  language     = {eng},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Abnormal peripheral chemokine profile in Huntington's disease.},
  url          = {http://dx.doi.org/10.1371/currents.RRN1231},
  volume       = {3},
  year         = {2011},
}