Advanced

Treatment of acute vestibular neuronitis with glucocorticoids.

Karlberg, Mikael LU and Magnusson, Måns LU (2011) In Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 32(7). p.1140-1143
Abstract
OBJECTIVE:

: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.



STUDY DESIGN:

: Prospective, consecutive case series compared with historic controls.



SETTING:

: Secondary referral academic hospital.



PATIENTS:

: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).



INTERVENTIONS:

: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous... (More)
OBJECTIVE:

: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.



STUDY DESIGN:

: Prospective, consecutive case series compared with historic controls.



SETTING:

: Secondary referral academic hospital.



PATIENTS:

: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).



INTERVENTIONS:

: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous betamethasone 8 mg on the first 1 to 2 days if nauseated.



MAIN OUTCOME MEASURES:

: Extent of unilateral vestibular paresis (%) in the caloric test at presentation and at 12 months of follow-up. Length of hospital stay (days).



RESULTS:

: The initial vestibular paresis value did not differ between the treatment group and the control group. At follow-up, the treatment group showed a lower value (22.8% versus 47.2%, p = 0.0003) and greater improvement (53.4% versus 35.6%, p = 0.002). At follow-up, 70% of the treatment group had a normal caloric test result compared to only 34% of the control group. The mean hospital stay of the treatment group was significantly shorter than that of the control group (1.8 versus 3.0 d, p = 0.001).



CONCLUSION:

: Glucocorticoids administered within 3 days after onset of vestibular neuronitis improves long-time recovery of vestibular function and reduces length of hospital stay (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
volume
32
issue
7
pages
1140 - 1143
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000293896300021
  • PMID:21817947
  • Scopus:80052270779
ISSN
1537-4505
DOI
10.1097/MAO.0b013e3182267e24
language
English
LU publication?
yes
id
6f252948-5064-4b71-937f-d6e32cd92c03 (old id 2151419)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21817947?dopt=Abstract
date added to LUP
2011-09-04 16:13:18
date last changed
2017-01-01 07:42:55
@article{6f252948-5064-4b71-937f-d6e32cd92c03,
  abstract     = {OBJECTIVE:<br/><br>
: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.<br/><br>
<br/><br>
STUDY DESIGN:<br/><br>
: Prospective, consecutive case series compared with historic controls.<br/><br>
<br/><br>
SETTING:<br/><br>
: Secondary referral academic hospital.<br/><br>
<br/><br>
PATIENTS:<br/><br>
: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).<br/><br>
<br/><br>
INTERVENTIONS:<br/><br>
: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous betamethasone 8 mg on the first 1 to 2 days if nauseated.<br/><br>
<br/><br>
MAIN OUTCOME MEASURES:<br/><br>
: Extent of unilateral vestibular paresis (%) in the caloric test at presentation and at 12 months of follow-up. Length of hospital stay (days).<br/><br>
<br/><br>
RESULTS:<br/><br>
: The initial vestibular paresis value did not differ between the treatment group and the control group. At follow-up, the treatment group showed a lower value (22.8% versus 47.2%, p = 0.0003) and greater improvement (53.4% versus 35.6%, p = 0.002). At follow-up, 70% of the treatment group had a normal caloric test result compared to only 34% of the control group. The mean hospital stay of the treatment group was significantly shorter than that of the control group (1.8 versus 3.0 d, p = 0.001).<br/><br>
<br/><br>
CONCLUSION:<br/><br>
: Glucocorticoids administered within 3 days after onset of vestibular neuronitis improves long-time recovery of vestibular function and reduces length of hospital stay},
  author       = {Karlberg, Mikael and Magnusson, Måns},
  issn         = {1537-4505},
  language     = {eng},
  number       = {7},
  pages        = {1140--1143},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  title        = {Treatment of acute vestibular neuronitis with glucocorticoids.},
  url          = {http://dx.doi.org/10.1097/MAO.0b013e3182267e24},
  volume       = {32},
  year         = {2011},
}