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Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants

Verhaegh, Suzanne J. C.; de Vogel, Corne P.; Riesbeck, Kristian LU ; Lafontaine, Eric R.; Murphy, Timothy F.; Verbrugh, Henri A.; Jaddoe, Vincent W. V.; Hofman, Albert; Moll, Henriette A. and van Belkum, Alex, et al. (2011) In Vaccine 29(34). p.5603-5610
Abstract
The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P <= 0.001). This was a most likely a consequence of maternal transmission of... (More)
The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P <= 0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1,UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
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keywords
Moraxella catarrhalis, Colonization, Immune response, Surface antigens, Vaccine, Children
in
Vaccine
volume
29
issue
34
pages
5603 - 5610
publisher
Elsevier
external identifiers
  • wos:000294145800005
  • scopus:79960565528
ISSN
1873-2518
DOI
10.1016/j.vaccine.2011.06.019
language
English
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yes
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d0072119-f0e6-47a4-91f2-fcd84475837b (old id 2160931)
date added to LUP
2011-10-03 08:31:12
date last changed
2017-11-05 03:10:46
@article{d0072119-f0e6-47a4-91f2-fcd84475837b,
  abstract     = {The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P &lt;= 0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1,UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events. (C) 2011 Elsevier Ltd. All rights reserved.},
  author       = {Verhaegh, Suzanne J. C. and de Vogel, Corne P. and Riesbeck, Kristian and Lafontaine, Eric R. and Murphy, Timothy F. and Verbrugh, Henri A. and Jaddoe, Vincent W. V. and Hofman, Albert and Moll, Henriette A. and van Belkum, Alex and Hays, John P.},
  issn         = {1873-2518},
  keyword      = {Moraxella catarrhalis,Colonization,Immune response,Surface antigens,Vaccine,Children},
  language     = {eng},
  number       = {34},
  pages        = {5603--5610},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2011.06.019},
  volume       = {29},
  year         = {2011},
}