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Characterization of the complete genomes of Camelus dromedarius papillomavirus types 1 and 2

Ure, Agustin LU ; Elfadl, A. K.; Khalafalla, A. I.; Gameel, A. A. R.; Dillner, Joakim LU and Forslund, Ola LU (2011) In Journal of General Virology 92(8). p.1769-1777
Abstract
Camel papillomatosis has been described previously, but the genome of the suspected papillomavirus (PV) has not been identified. An outbreak of papillomatosis occurred in a dromedary farm of 55 animals in Sudan during August 2009. The disease was only present in young animals aged about 3-7 months, of which 44% (11/25) were affected with lesions, mainly on the lips and lower jaw. This study reports for the first time the complete genomes of Camelus dromedarius papillomavirus types 1 (CdPV1) and 2 (CdPV2), isolated from a cauliflower-like nodule and a round oval raised nodule, respectively. Pairwise comparisons of their L1 nucleotide sequences revealed 69.2% identity, and phylogenetic analyses suggested that these two PV types are grouped... (More)
Camel papillomatosis has been described previously, but the genome of the suspected papillomavirus (PV) has not been identified. An outbreak of papillomatosis occurred in a dromedary farm of 55 animals in Sudan during August 2009. The disease was only present in young animals aged about 3-7 months, of which 44% (11/25) were affected with lesions, mainly on the lips and lower jaw. This study reports for the first time the complete genomes of Camelus dromedarius papillomavirus types 1 (CdPV1) and 2 (CdPV2), isolated from a cauliflower-like nodule and a round oval raised nodule, respectively. Pairwise comparisons of their L1 nucleotide sequences revealed 69.2% identity, and phylogenetic analyses suggested that these two PV types are grouped within the genus Deltapapillomavirus. Both viruses were isolated from fibropapillomas, although no putative E5 proteins homologous to that of bovine papillomavirus type 1 were identified. The genetic information will be useful for evolutionary studies of the family Papillomaviridae, as well as for the development of diagnostic methods for surveillance of the disease in dromedaries. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of General Virology
volume
92
issue
8
pages
1769 - 1777
publisher
Society for General Microbiology
external identifiers
  • wos:000293488800004
  • scopus:79960379035
ISSN
1465-2099
DOI
10.1099/vir.0.031039-0
language
English
LU publication?
yes
id
dd291158-1e30-4dd0-8350-97dc4ea61b85 (old id 2161950)
date added to LUP
2011-10-03 08:36:18
date last changed
2017-10-01 04:21:44
@article{dd291158-1e30-4dd0-8350-97dc4ea61b85,
  abstract     = {Camel papillomatosis has been described previously, but the genome of the suspected papillomavirus (PV) has not been identified. An outbreak of papillomatosis occurred in a dromedary farm of 55 animals in Sudan during August 2009. The disease was only present in young animals aged about 3-7 months, of which 44% (11/25) were affected with lesions, mainly on the lips and lower jaw. This study reports for the first time the complete genomes of Camelus dromedarius papillomavirus types 1 (CdPV1) and 2 (CdPV2), isolated from a cauliflower-like nodule and a round oval raised nodule, respectively. Pairwise comparisons of their L1 nucleotide sequences revealed 69.2% identity, and phylogenetic analyses suggested that these two PV types are grouped within the genus Deltapapillomavirus. Both viruses were isolated from fibropapillomas, although no putative E5 proteins homologous to that of bovine papillomavirus type 1 were identified. The genetic information will be useful for evolutionary studies of the family Papillomaviridae, as well as for the development of diagnostic methods for surveillance of the disease in dromedaries.},
  author       = {Ure, Agustin and Elfadl, A. K. and Khalafalla, A. I. and Gameel, A. A. R. and Dillner, Joakim and Forslund, Ola},
  issn         = {1465-2099},
  language     = {eng},
  number       = {8},
  pages        = {1769--1777},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Characterization of the complete genomes of Camelus dromedarius papillomavirus types 1 and 2},
  url          = {http://dx.doi.org/10.1099/vir.0.031039-0},
  volume       = {92},
  year         = {2011},
}