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Continuous flow microfluidic separation and processing of rare cells and bioparticles found in blood – A review

Antfolk, Maria LU and Laurell, Thomas LU (2017) In Analytica Chimica Acta 965. p.9-35
Abstract

Rare cells in blood, such as circulating tumor cells or fetal cells in the maternal circulation, posses a great prognostic or diagnostic value, or for the development of personalized medicine, where the study of rare cells could provide information to more specifically targeted treatments. When conventional cell separation methods, such as flow cytometry or magnetic activated cell sorting, have fallen short other methods are desperately sought for. Microfluidics have been extensively used towards isolating and processing rare cells as it offers possibilities not present in the conventional systems. Furthermore, microfluidic methods offer new possibilities for cell separation as they often rely on non-traditional biomarkers and intrinsic... (More)

Rare cells in blood, such as circulating tumor cells or fetal cells in the maternal circulation, posses a great prognostic or diagnostic value, or for the development of personalized medicine, where the study of rare cells could provide information to more specifically targeted treatments. When conventional cell separation methods, such as flow cytometry or magnetic activated cell sorting, have fallen short other methods are desperately sought for. Microfluidics have been extensively used towards isolating and processing rare cells as it offers possibilities not present in the conventional systems. Furthermore, microfluidic methods offer new possibilities for cell separation as they often rely on non-traditional biomarkers and intrinsic cell properties. This offers the possibility to isolate cell populations that would otherwise not be targeted using conventional methods. Here, we provide an extensive review of the latest advances in continuous flow microfluidic rare cell separation and processing with each cell's specific characteristics and separation challenges as a point of view.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell separation, CTC, Microfluidics, nRBC, Rare cell
in
Analytica Chimica Acta
volume
965
pages
27 pages
publisher
Elsevier
external identifiers
  • scopus:85016409950
  • wos:000398435400007
ISSN
0003-2670
DOI
10.1016/j.aca.2017.02.017
language
English
LU publication?
yes
id
2163eb17-da8c-449f-92dc-f6889717f24e
date added to LUP
2017-04-11 12:20:31
date last changed
2017-09-18 13:32:10
@article{2163eb17-da8c-449f-92dc-f6889717f24e,
  abstract     = {<p>Rare cells in blood, such as circulating tumor cells or fetal cells in the maternal circulation, posses a great prognostic or diagnostic value, or for the development of personalized medicine, where the study of rare cells could provide information to more specifically targeted treatments. When conventional cell separation methods, such as flow cytometry or magnetic activated cell sorting, have fallen short other methods are desperately sought for. Microfluidics have been extensively used towards isolating and processing rare cells as it offers possibilities not present in the conventional systems. Furthermore, microfluidic methods offer new possibilities for cell separation as they often rely on non-traditional biomarkers and intrinsic cell properties. This offers the possibility to isolate cell populations that would otherwise not be targeted using conventional methods. Here, we provide an extensive review of the latest advances in continuous flow microfluidic rare cell separation and processing with each cell's specific characteristics and separation challenges as a point of view.</p>},
  author       = {Antfolk, Maria and Laurell, Thomas},
  issn         = {0003-2670},
  keyword      = {Cell separation,CTC,Microfluidics,nRBC,Rare cell},
  language     = {eng},
  month        = {05},
  pages        = {9--35},
  publisher    = {Elsevier},
  series       = {Analytica Chimica Acta},
  title        = {Continuous flow microfluidic separation and processing of rare cells and bioparticles found in blood – A review},
  url          = {http://dx.doi.org/10.1016/j.aca.2017.02.017},
  volume       = {965},
  year         = {2017},
}